| General Information |
| MoonProt ID | 255 |
| First appeared in release | 1.0 |
| Name(s) | Hal3
Phosphopantothenoylcysteine decarboxylase subunit SIS2
Halotolerance protein HAL3
Sit4 suppressor 2
Gene Name:SIS2
|
| UniProt ID | P36024 (SIS2_YEAST), Reviewed |
| GO terms | GO:0007346 regulation of mitotic cell cycle
GO:0009651 response to salt stress
GO:0015937 coenzyme A biosynthetic process
GO:0043086 negative regulation of catalytic activity
GO:0003824 catalytic activity
GO:0004633 phosphopantothenoylcysteine decarboxylase activity
GO:0004864 protein phosphatase inhibitor activity
GO:0005515 protein binding
GO:0004633 phosphopantothenoylcysteine decarboxylase activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0071513 phosphopantothenoylcysteine decarboxylase complex |
| Organisms for which functions have been demonstrated | Saccharomyces cerevisiae (yeast, fungi) |
| Sequence length | 562 |
| FASTA sequence | >sp|P36024|SIS2_YEAST Phosphopantothenoylcysteine decarboxylase subunit SIS2 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=SIS2 PE=1 SV=1
MTAVASTSGKQDADHNQSIECPRFSRGQKEILLDHEDAKGKDSIINSPVSGRQSISPTLSNATTTTTKSIMNATGTSGAVVSNTPEPGLKRVPAVTFSDLKQQQKQDSLTQLKNDSERTKSPNSNPAPVSNSIPGNHAVIPNHTNTSRTTQLSGSPLVNEMKDYDPKKKDSALKIVDTMKPDKIMATSTPISRENNKVTAKAPTSITLRKEDAQDQANNVSGQINVRSTPEETPVKQSVIPSIIPKRENSKNLDPRLPQDDGKLHVLFGATGSLSVFKIKPMIKKLEEIYGRDRISIQVILTQSATQFFEQRYTKKIIKSSEKLNKMSQYESTPATPVTPTPGQCNMAQVVELPPHIQLWTDQDEWDAWKQRTDPVLHIELRRWADILVVAPLTANTLSKIALGLCDNLLTSVIRAWNPSYPILLAPSMVSSTFNSMMTKKQLQTIKEEMSWVTVFKPSEKVMDINGDIGLGGMMDWNEIVNKIVMKLGGYPKNNEEEDDDEDEEEDDDEEEDTEDKNENNNDDDDDDDDDDDDDDDDDDDDDDDDEDEDEAETPGIIDKHQ
|
| Structure Information |
| PDB ID | None, closest homologue is different species, 36.56% Chain A, Hypothetical Protein Mds018 [Homo sapiens] 1QZU |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-20, 24-65, 71-168, 177-254, 322-345, 492-562 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Subunit of phosphopantothenoylcysteine decarboxylase (PPCDC)
coenzyme A biosynthesis pathway
|
| References for function | |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | inhibitory subunit of protein phosphatase PPZ1
|
| References for function | Ruiz A, Gonz?lez A, Mu?oz I, Serrano R, Abrie JA, Strauss E, Ari?o J. Moonlighting proteins Hal3 and Vhs3 form a heteromeric PPCDC with Ykl088w in yeast CoA biosynthesis. Nat Chem Biol. 2009 Dec;5(12):920-8. doi: 10.1038/nchembio.243.
PMID: 19915539 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |