| General Information |
| MoonProt ID | 256 |
| First appeared in release | 1.0 |
| Name(s) | Phosphopantothenoylcysteine decarboxylase subunit VHS3
Viable in a HAL3 SIT4 background protein 3
Gene Name:VHS3 |
| UniProt ID | Q08438 (VHS3_YEAST), Reviewed |
| GO terms | GO:0007049 cell cycle
GO:0015937 coenzyme A biosynthetic process
GO:0030004 cellular monovalent inorganic cation homeostasis
GO:0043086 negative regulation of catalytic activity
GO:0003824 catalytic activity
GO:0004633 phosphopantothenoylcysteine decarboxylase activity
GO:0004864 protein phosphatase inhibitor activity
GO:0005515 protein binding
GO:0004633 phosphopantothenoylcysteine decarboxylase activity
GO:0071513 phosphopantothenoylcysteine decarboxylase complex |
| Organisms for which functions have been demonstrated | Saccharomyces cerevisiae (yeast, fungi) |
| Sequence length | 674 |
| FASTA sequence | >sp|Q08438|VHS3_YEAST Phosphopantothenoylcysteine decarboxylase subunit VHS3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=VHS3 PE=1 SV=1
MTNKSSLKNNRKGVASNTLSGAEQANIGSSAMPDTNSTGPFSSVSSLDTPVVRKSTSPTGSQTKSIMNASGTSGAVVSNTPEPGLKRIPTVTFSDPKLGSLRSDVEQTPPNQVARQSSEKKATSVHIAAEGANQGRNLKDINTKVPKDGEASASSFSTPTSILSNADMGNNISSLLAKKLSFTGGTDSILNSDNSSDSPRKEHPHFYVEDPLHTPSVRSRSNSTSPRPSVVVNTFNPINIEREGSISKTGEPTLLESVLEEAMSPNAVSNPLKRENIMTNMDPRLPQDDGKLHVLFGATGSLSVFKLKHMIRKLEEIYGRDKICIQVILTNSATKFFAMKYMRKNKKQHNSIDTSFNSTNSNAGNITGNKKKVASLEKFSIQKTSSNSAASQTNNKQEEEKQMASTTGFPSTLGGSRTYSNSSNVVSQHPQIELPAHIQFWTDQDEWDVWRQRTDPVLHIELRRWADILVVAPLTANTLAKIALGLCDNLLTSVIRAWNPTFPIFLAPSMGSGTFNSIMTKKHFRIIQEEMPWVTVFKPSEKVMGINGDIGLSGMMDANEIVGKIVVKLGGYPDVSAGKEEEEDEDNDEEDDNKKNDTGGKDEDNDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDDEDDEDEDEDDEGKKKEDKGGLQRS
|
| Structure Information |
| PDB ID | None, closest homologue is different species, 46.67% Chain A, HALOTOLERANCE PROTEIN HAL3 [Arabidopsis thaliana] 1E20 |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-79, 98-203, 210-283, 343-372, 379-430, 573-674 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Subunit of phosphopantothenoylcysteine decarboxylase (PPCDC)
coenzyme A biosynthesis pathway |
| References for function | |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | inhibitory subunit of protein phosphatase PPZ1 |
| References for function | Ruiz A, Gonz?lez A, Mu?oz I, Serrano R, Abrie JA, Strauss E, Ari?o J. Moonlighting proteins Hal3 and Vhs3 form a heteromeric PPCDC with Ykl088w in yeast CoA biosynthesis. Nat Chem Biol. 2009 Dec;5(12):920-8. doi: 10.1038/nchembio.243.
PMID: 19915539 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |