| General Information |
| MoonProt ID | 257 |
| First appeared in release | 1.0 |
| Name(s) | Intron-associated endonuclease 1
I-TevI
IRF protein
Gene Name:ITEVIR |
| UniProt ID | P13299 (TEV1_BPT4), Reviewed |
| GO terms | GO:0006314 intron homing
GO:0090305 nucleic acid phosphodiester bond hydrolysis
GO:0003677 DNA binding
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0016787 hydrolase activity |
| Organisms for which functions have been demonstrated | bacteriophage T4 |
| Sequence length | 245 |
| FASTA sequence | >sp|P13299|TEV1_BPT4 Intron-associated endonuclease 1 OS=Enterobacteria phage T4 GN=ITEVIR PE=1 SV=2
MKSGIYQIKNTLNNKVYVGSAKDFEKRWKRHFKDLEKGCHSSIKLQRSFNKHGNVFECSILEEIPYEKDLIIERENFWIKELNSKINGYNIADATFGDTCSTHPLKEEIIKKRSETVKAKMLKLGPDGRKALYSKPGSKNGRWNPETHKFCKCGVRIQTSAYTCSKCRNRSGENNSFFNHKHSDITKSKISEKMKGKKPSNIKKISCDGVIFDCAADAARHFKISSGLVTYRVKSDKWNWFYINA
|
| Structure Information |
| PDB ID | 1I3J
1MK0
1LN0 |
| Quaternary structure | |
| SCOP | DNA-binding domain of intron-encoded endonucleases |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-2, 96-117, 125-128, 135-197, 243-245 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | homing endonuclease, enzyme
intron-encoded
binds cognate intronless alleles
|
| References for function | West DK, Changchien LM, Maley GF, Maley F. Evidence that the intron open reading frame of the phage T4 td gene encodes a specific endonuclease. J Biol Chem. 1989 Jun 25;264(18):10343-6.
PMID: 2543665 |
| E.C. number | 3.1.-.- |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm, bound to DNA |
| Comments | |
| Function 2 |
| Function description | transcriptional autorepressor
|
| References for function | Edgell DR, Derbyshire V, Van Roey, LaBonne S, Stanger MJ, Li Z, Boyd TM, Shub DA, Belfort M. Intron-encoded homing endonuclease I-TevI also functions as a transcriptional autorepressor. Nat Struct Mol Biol. 2004 Oct;11(10):936-44. PMID: 15361856 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm, bound to DNA |
| Comments | |