| General Information |
| MoonProt ID | 260 |
| First appeared in release | 1.0 |
| Name(s) | MDR1
Multidrug resistance protein 1
ATP-binding cassette sub-family B member 1
P-glycoprotein 1
CD_antigen=CD243
Gene Name:ABCB1 |
| UniProt ID | P08183 (MDR1_HUMAN), Reviewed |
| GO terms | GO:0000086 G2/M transition of mitotic cell cycle
GO:0006200 ATP catabolic process
GO:0006810 transport
GO:0006855 drug transmembrane transport
GO:0042493 response to drug
GO:0042908 xenobiotic transport
GO:0044281 small molecule metabolic process
GO:0055085 transmembrane transport
GO:0072089 stem cell proliferation
GO:0000166 nucleotide binding
GO:0005215 transporter activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008559 xenobiotic-transporting ATPase activity
GO:0016787 hydrolase activity
GO:0016887 ATPase activity
GO:0017111 nucleoside-triphosphatase activity
GO:0042626 ATPase activity, coupled to transmembrane movement of substances
GO:0000139 Golgi membrane
GO:0005886 plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0046581 intercellular canaliculus
GO:0070062 extracellular vesicular exosome |
| Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal) |
| Sequence length | 1280 |
| FASTA sequence | >sp|P08183|MDR1_HUMAN Multidrug resistance protein 1 OS=Homo sapiens GN=ABCB1 PE=1 SV=3
MDLEGDRNGGAKKKNFFKLNNKSEKDKKEKKPTVSVFSMFRYSNWLDKLYMVVGTLAAIIHGAGLPLMMLVFGEMTDIFANAGNLEDLMSNITNRSDINDTGFFMNLEEDMTRYAYYYSGIGAGVLVAAYIQVSFWCLAAGRQIHKIRKQFFHAIMRQEIGWFDVHDVGELNTRLTDDVSKINEGIGDKIGMFFQSMATFFTGFIVGFTRGWKLTLVILAISPVLGLSAAVWAKILSSFTDKELLAYAKAGAVAEEVLAAIRTVIAFGGQKKELERYNKNLEEAKRIGIKKAITANISIGAAFLLIYASYALAFWYGTTLVLSGEYSIGQVLTVFFSVLIGAFSVGQASPSIEAFANARGAAYEIFKIIDNKPSIDSYSKSGHKPDNIKGNLEFRNVHFSYPSRKEVKILKGLNLKVQSGQTVALVGNSGCGKSTTVQLMQRLYDPTEGMVSVDGQDIRTINVRFLREIIGVVSQEPVLFATTIAENIRYGRENVTMDEIEKAVKEANAYDFIMKLPHKFDTLVGERGAQLSGGQKQRIAIARALVRNPKILLLDEATSALDTESEAVVQVALDKARKGRTTIVIAHRLSTVRNADVIAGFDDGVIVEKGNHDELMKEKGIYFKLVTMQTAGNEVELENAADESKSEIDALEMSSNDSRSSLIRKRSTRRSVRGSQAQDRKLSTKEALDESIPPVSFWRIMKLNLTEWPYFVVGVFCAIINGGLQPAFAIIFSKIIGVFTRIDDPETKRQNSNLFSLLFLALGIISFITFFLQGFTFGKAGEILTKRLRYMVFRSMLRQDVSWFDDPKNTTGALTTRLANDAAQVKGAIGSRLAVITQNIANLGTGIIISFIYGWQLTLLLLAIVPIIAIAGVVEMKMLSGQALKDKKELEGSGKIATEAIENFRTVVSLTQEQKFEHMYAQSLQVPYRNSLRKAHIFGITFSFTQAMMYFSYAGCFRFGAYLVAHKLMSFEDVLLVFSAVVFGAMAVGQVSSFAPDYAKAKISAAHIIMIIEKTPLIDSYSTEGLMPNTLEGNVTFGEVVFNYPTRPDIPVLQGLSLEVKKGQTLALVGSSGCGKSTVVQLLERFYDPLAGKVLLDGKEIKRLNVQWLRAHLGIVSQEPILFDCSIAENIAYGDNSRVVSQEEIVRAAKEANIHAFIESLPNKYSTKVGDKGTQLSGGQKQRIAIARALVRQPHILLLDEATSALDTESEKVVQEALDKAREGRTCIVIAHRLSTIQNADLIVVFQNGRVKEHGTHQQLLAQKGIYFSMVSVQAGTKRQ
|
| Structure Information |
| PDB ID | 6C0V, 6QEX |
| Quaternary structure | |
| SCOP | |
| CATH | |
| TM Helix Prediction | 10(49-71,114-136,190-212,217-239,295-317,710-732,753-775,852-874,937-959,974-996) |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-32, 90-101, 241-247, 378-381, 632-691, 882-893, 1016-1026, 1273-1280 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | transmembrane transporter
efflux pump, uses ATP for energy
expels drugs and other small molecule compounds
ATP + H2O + xenobiotic(Inside) => ADP + phosphate + xenobiotic(Outside) |
| References for function | |
| E.C. number | 3.6.3.44 |
| Location of functional site(s) | |
| Cellular location of function | plasma membrane, transmembrane protein |
| Comments | |
| Function 2 |
| Function description | regulator of volume-activated chloride channels
|
| References for function | Hardy SP, Goodfellow HR, Valverde MA, Gill DR, Sep?lveda V, Higgins CF. Protein kinase C-mediated phosphorylation of the human multidrug resistance P-glycoprotein regulates cell volume-activated chloride channels. EMBO J. 1995 Jan 3;14(1):68-75. PMID: 7828597 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | plasma membrane, transmembrane protein |
| Comments | |