| General Information |
| MoonProt ID | 267 |
| First appeared in release | 1.0 |
| Name(s) | Vacuolar protein-sorting-associated protein 36
ESCRT-II complex subunit VPS36
Gene Name: Vps36 |
| UniProt ID | Q9VU87 (VPS36_DROME), Reviewed |
| GO terms | GO:0006810 transport
GO:0007224 smoothened signaling pathway
GO:0008283 cell proliferation
GO:0008593 regulation of Notch signaling pathway
GO:0015031 protein transport
GO:0042981 regulation of apoptotic process
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0051028 mRNA transport
GO:0003723 RNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0043130 ubiquitin binding
GO:0000814 ESCRT II complex
GO:0005737 cytoplasm
GO:0005768 endosome
|
| Organisms for which functions have been demonstrated | Drosophila melanogaster (fruit fly, an insect) |
| Sequence length | 399 |
| FASTA sequence | >sp|Q9VU87|VPS36_DROME Vacuolar protein-sorting-associated protein 36 OS=Drosophila melanogaster GN=Vps36 PE=2 SV=2
MNRFAYVEARLSPNESFVSRDNRVKIYDGDQKTDFEDGEVVLTTHRLFWGRPGEIARAAVTLCLPLSYVISVSEETTASNFFGRKTRIIMHLHPPTSDKGPGPLDTSRATHIKLSGKNGLSVEFHSALRETLNARVWEILLTSEIIINGVASSPTLEPANDRLARIQKRTGIGGIERHLEAKAKATDENIALAFQDLSVLMAMAKDMVGVSKTISSKIRKQKGEISDDETVRFKSYLMSLGIDDPVTRDNFTSNSAYFSSLARQICEMLLDPIEEQGGMMSLADVYCRVNRARGLELLSPEDLLHACEQLSGPIRLRSFPSGARVLQLESHDDALIAVDTLEKVEAAESLAVEELAKQLGISLLLAKERLLVAERLGKVCRDESVEGLRFYPNLLLGRD
|
| Structure Information |
| PDB ID | None, closest homologue is different species, 56.09% Chain B, Vacuolar Protein-sorting-associated Protein 36 [Homo sapiens] 2ZME |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-3, 6, 73-105, 180-189, 216-233, 398-399 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Component of the ESCRT-II complex (ensodomal sorting complex required for transport II) complex
needed for sorting ubiquitinated endosomal proteins into multivesicular bodies
important for transport of transmembrane proteins to the lysosome for degradation |
| References for function | |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm, endosomal membrane |
| Comments | |
| Function 2 |
| Function description | mRNA binding
binds to the localization element in the 3' untranslated region (UTR) of bicoid mRNA
functions in localizing bicoid mRNA to the anterior of the Drosophila egg |
| References for function | Irion U, St Johnston. bicoid RNA localization requires specific binding of an endosomal sorting complex. Nature. 2007 Feb 1. PMID: 17268469 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |