| General Information |
| MoonProt ID | 27 |
| First appeared in release | 1.0 |
| Name(s) | enolase
2-phospho-D-glycerate hydro-lyase
2-phosphoglycerate dehydratase
Gene Name: eno
|
| UniProt ID | B7J1R2 (ENO_BORBZ), Reviewed |
| GO terms | GO:0006096 glycolysis
GO:0000287 magnesium ion binding
GO:0004634 phosphopyruvate hydratase activity
GO:0016829 lyase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0000015 phosphopyruvate hydratase complex
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0009986 cell surface |
| Organisms for which functions have been demonstrated | Borrelia burgdorferi (Lyme disease) |
| Sequence length | 433 |
| FASTA sequence | >sp|B7J1R2|ENO_BORBZ Enolase OS=Borrelia burgdorferi (strain ZS7) GN=eno PE=3 SV=1
MGFHIYEIKARQIIDSRGNPTVEADVILEDGTYGRAAVPSGASTGINEAVELRDGDKSVYMGKGVLKAIENIKNIIAPELEGMSALNQVAIDRKMLELDGTPTKEKLGANAILAVSMATAKAAAKYLGLRPYQYLGAYKANILPTPMCNIINGGAHSDNSVDFQEFMIMPIGAKTFSEAIRMAAEVFHTLKGILSGKGYATSVGDEGGFAPNLKSNEEACEVIIEAIKKAGYEPGKDIAIALDPATSELYDPKTKKYVLKWSTKEELTSEQMVEYWAKWVEKYPIISIEDGMAEEDWDGWKKLTDKIGNKIQLVGDDLFVTNTSFLKKGIEMGVANSILIKVNQIGTLTETFEAVEMAKKAGYTAIVSHRSGETEDTTIADLVVALGTGQIKTGSLSRTDRIAKYNQLIRIEEELETTAEYHGKSVFYSIKQK
|
| Structure Information |
| PDB ID | Closest homologue is 4IYX (66.28%) |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-4,42-43,430-433 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enolase, enzyme
2-phospho-D-glycerate => phosphoenolpyruvate + H2O
reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. Carbohydrate degradation, glycolysis |
| References for function | |
| E.C. number | 4.2.1.11 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | plasminogen binding
(binds human plasminogen) |
| References for function | Floden AM, Watt JA, Brissette CA (2011) Borrelia burgdorferi Enolase Is a Surface-Exposed Plasminogen Binding Protein. PLoS One. 2011;6(11):e27502. doi: 10.1371/journal.pone.0027502. Epub 2011 Nov 8.PMID:22087329 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |