| General Information |
| MoonProt ID | 270 |
| First appeared in release | 1.0 |
| Name(s) | ribosomal protein S14
Gene Name:RPS14 |
| UniProt ID | P62263 (RS14_HUMAN), Reviewed |
| GO terms | GO:0000028 ribosomal small subunit assembly
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006412 translation
GO:0006413 translational initiation
GO:0006414 translational elongation
GO:0006415 translational termination
GO:0006417 regulation of translation
GO:0006614 SRP-dependent cotranslational protein targeting to membrane
GO:0010467 gene expression
GO:0016032 viral process
GO:0016070 RNA metabolic process
GO:0016071 mRNA metabolic process
GO:0019058 viral life cycle
GO:0019083 viral transcription
GO:0030218 erythrocyte differentiation
GO:0030490 maturation of SSU-rRNA
GO:0044267 cellular protein metabolic process
GO:0003723 RNA binding
GO:0003735 structural constituent of ribosome
GO:0044822 poly(A) RNA binding
GO:0045182 translation regulator activity
GO:0048027 mRNA 5'-UTR binding
GO:0005730 nucleolus
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005840 ribosome
GO:0022627 cytosolic small ribosomal subunit
GO:0030529 ribonucleoprotein complex
GO:0070062 extracellular vesicular exosome |
| Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal, OMIM number 130620 Macrocytic anemia) |
| Sequence length | |
| FASTA sequence | >sp|P62263|RS14_HUMAN 40S ribosomal protein S14 OS=Homo sapiens GN=RPS14 PE=1 SV=3
MAPRKGKEKKEEQVISLGPQVAEGENVFGVCHIFASFNDTFVHVTDLSGKETICRVTGGMKVKADRDESSPYAAMLAAQDVAQRCKELGITALHIKLRATGGNRTKTPGPGAQSALRALARSGMKIGRIEDVTPIPSDSTRRKGGRRGRRL
|
| Structure Information |
| PDB ID | NA |
| Quaternary structure | |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-15, 102-108, 140-151 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | ribosomal protein
|
| References for function | NA |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm, part of the ribosome |
| Comments | |
| Function 2 |
| Function description | inhibits S14 mRNA transcription
negative effector of transcription of its own RNA
|
| References for function | Tasheva ES, Roufa DJ. Regulation of human RPS14 transcription by intronic antisense RNAs and ribosomal protein S14. Genes Dev. 1995 Feb 1;9(3):304-16. PMID: 7867928 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |