| General Information |
| MoonProt ID | 271 |
| First appeared in release | 1.0 |
| Name(s) | Signal transducer and activator of transcription 3
Acute-phase response factor
Gene Name:Stat3 |
| UniProt ID | P42227 (STAT3_MOUSE), Reviewed |
| GO terms | GO:0001659 temperature homeostasis
GO:0001754 eye photoreceptor cell differentiation
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
GO:0006606 protein import into nucleus
GO:0006953 acute-phase response
GO:0007165 signal transduction
GO:0007259 JAK-STAT cascade
GO:0008283 cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0010033 response to organic substance
GO:0014070 response to organic cyclic compound
GO:0016310 phosphorylation
GO:0019221 cytokine-mediated signaling pathway
GO:0019827 stem cell maintenance
GO:0019953 sexual reproduction
GO:0030522 intracellular receptor signaling pathway
GO:0032355 response to estradiol
GO:0032870 cellular response to hormone stimulus
GO:0034097 response to cytokine
GO:0040014 regulation of multicellular organism growth
GO:0042493 response to drug
GO:0042593 glucose homeostasis
GO:0042755 eating behavior
GO:0043434 response to peptide hormone
GO:0045471 response to ethanol
GO:0045747 positive regulation of Notch signaling pathway
GO:0045820 negative regulation of glycolytic process
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048708 astrocyte differentiation
GO:0060019 radial glial cell differentiation
GO:0060396 growth hormone receptor signaling pathway
GO:0060397 JAK-STAT cascade involved in growth hormone signaling pathway
GO:0060548 negative regulation of cell death
GO:0070102 interleukin-6-mediated signaling pathway
GO:2001223 negative regulation of neuron migration
GO:0000981 sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0001103 RNA polymerase II repressing transcription factor binding
GO:0003677 DNA binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004871 signal transducer activity
GO:0004879 ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019901 protein kinase binding
GO:0019903 protein phosphatase binding
GO:0031730 CCR5 chemokine receptor binding
GO:0035259 glucocorticoid receptor binding
GO:0043565 sequence-specific DNA binding
GO:0044212 transcription regulatory region DNA binding
GO:0046983 protein dimerization activity
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane |
| Organisms for which functions have been demonstrated | Mus musculus (Mouse, mammal) |
| Sequence length | 770 |
| FASTA sequence | >sp|P42227|STAT3_MOUSE Signal transducer and activator of transcription 3 OS=Mus musculus GN=Stat3 PE=1 SV=2
MAQWNQLQQLDTRYLEQLHQLYSDSFPMELRQFLAPWIESQDWAYAASKESHATLVFHNLLGEIDQQYSRFLQESNVLYQHNLRRIKQFLQSRYLEKPMEIARIVARCLWEESRLLQTAATAAQQGGQANHPTAAVVTEKQQMLEQHLQDVRKRVQDLEQKMKVVENLQDDFDFNYKTLKSQGDMQDLNGNNQSVTRQKMQQLEQMLTALDQMRRSIVSELAGLLSAMEYVQKTLTDEELADWKRRQQIACIGGPPNICLDRLENWITSLAESQLQTRQQIKKLEELQQKVSYKGDPIVQHRPMLEERIVELFRNLMKSAFVVERQPCMPMHPDRPLVIKTGVQFTTKVRLLVKFPELNYQLKIKVCIDKDSGDVAALRGSRKFNILGTNTKVMNMEESNNGSLSAEFKHLTLREQRCGNGGRANCDASLIVTEELHLITFETEVYHQGLKIDLETHSLPVVVISNICQMPNAWASILWYNMLTNNPKNVNFFTKPPIGTWDQVAEVLSWQFSSTTKRGLSIEQLTTLAEKLLGPGVNYSGCQITWAKFCKENMAGKGFSFWVWLDNIIDLVKKYILALWNEGYIMGFISKERERAILSTKPPGTFLLRFSESSKEGGVTFTWVEKDISGKTQIQSVEPYTKQQLNNMSFAEIIMGYKIMDATNILVSPLVYLYPDIPKEEAFGKYCRPESQEHPEADPGSAAPYLKTKFICVTPTTCSNTIDLPMSPRTLDSLMQFGNNGEGAEPSAGGQFESLTFDMDLTSECATSPM |
| Structure Information |
| PDB ID | 4E68,
1BG1,
2CWG |
| Quaternary structure | |
| SCOP | NA |
| CATH | 1.20.1050.20, 2.60.40.630, 1.10.238.10, 3.30.505.10 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-6, 120-140, 181-197, 370-388, 397-403, 716-751, 760-770 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | transcription factor, binds DNA
in response to cytokines (IL-6, and other growth factors)
binds promoters containing IL-6 responsive elements
|
| References for function | |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm, nucleus |
| Comments | |
| Function 2 |
| Function description | modulates the activities of complexes I and II of the electron transport chain (ETC) in the mitochondria |
| References for function | Wegrzyn J, Potla R, Chwae YJ, Sepuri NB, Zhang Q, Koeck T, Derecka M, Szczepanek K, Szelag M, Gornicka A, Moh A, Moghaddas S, Chen Q, Bobbili S, Cichy J, Dulak J, Baker DP, Wolfman A, Stuehr D, Hassan MO, Fu XY, Avadhani N, Drake JI, Fawcett P, Lesnefsky EJ, Larner AC. Function of mitochondrial Stat3 in cellular respiration. Science. 2009 Feb 6;323(5915):793-7. doi: 10.1126/science.1164551.
PMID: 19131594 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | mitochondrion |
| Comments | |