| General Information |
| MoonProt ID | 274 |
| First appeared in release | 1.0 |
| Name(s) | Fructose-bisphosphate aldolase
|
| UniProt ID | S8GE25 (S8GE25_TOXGO), Unreviewed |
| GO terms | GO:0006096 glycolytic process
GO:0003824 catalytic activity
GO:0004332 fructose-bisphosphate aldolase activity
GO:0016829 lyase activity |
| Organisms for which functions have been demonstrated | Toxoplasma gondii |
| Sequence length | 433 |
| FASTA sequence | >tr|S8GE25|S8GE25_TOXGO Fructose-bisphosphate aldolase OS=Toxoplasma gondii ME49 GN=TGME49_236040 PE=3 SV=1
MLCIVERIAMPTRGVNPSAANGKLPPRTRSATGCRVYIHPMVKFISLLFAVFYARFFLLFCVRIQSTFPTMSGYGLPISQEVAKELAENARKIAAPGKGILAADESTGTIKKRFDSIGVENTEANRAFYRDLLFSTKGLGQYISGAILFEETLYQKSPSGVPMVDLLKAEGIIPGIKVDKGLETLPLTDDEKATMGLDGLSERCKKYYEAGARFAKWRAVLSIDPAKGKPTNLSITEVAHGLARYAAICQANRLVPIVEPEILTDGSHDITVCAEVTERVLAAVFKALNDHHVLLEGALLKPNMVTHGSDCPKPASHEEIAFYTVRSLKRTVPPALPGVMFLSGGQSEEDASLNLNEMNKMGPHPFQLSFSYGRALQASCLKAWKGVPENKAKAQQVLMERARANGEAQLGKYGGGAGGAAAASSLFEKRYVY
|
| Structure Information |
| PDB ID | 4D2J, 5TJS |
| Quaternary structure | |
| SCOP | TIM beta/alpha-barrel |
| CATH | 3.20.20.70 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-32, 414-424, 432-433 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Fructose-bisphosphate aldolase, enzyme
D-fructose 1,6-bisphosphate => dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate
Carbohydrate degradation, glycolysis |
| References for function | |
| E.C. number | 4.1.2.13 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | protein-protein interactions
couples actin cytoskeleton filaments in the cytoplasm to the surface adhesin microneme protein 2 (MIC2) |
| References for function | Starnes GL, Coincon M, Sygusch J, Sibley LD. Aldolase is essential for energy production and bridging adhesin-actin cytoskeletal interactions during parasite invasion of host cells. Cell Host Microbe. 2009 Apr 23;5(4):353-64. doi: 10.1016/j.chom.2009.03.005.
PMID: 19380114 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm, near plasma membrane |
| Comments | |