| General Information |
| MoonProt ID | 276 |
| First appeared in release | 1.0 |
| Name(s) | Lactose synthetase
Beta-1,4-galactosyltransferase 1
Beta-1,4-GalTase 1
Beta4Gal-T1
b4Gal-T1
UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 1
UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 1
Lactose synthase A protein
N-acetyllactosamine synthase
Nal synthase
Beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase
Gene Name: B4GALT1 |
| UniProt ID | P08037 (B4GT1_BOVIN), Reviewed |
| GO terms | GO:0002064 epithelial cell development
GO:0002526 acute inflammatory response
GO:0005975 carbohydrate metabolic process
GO:0005989 lactose biosynthetic process
GO:0006012 galactose metabolic process
GO:0006486 protein glycosylation
GO:0006487 protein N-linked glycosylation
GO:0007155 cell adhesion
GO:0007339 binding of sperm to zona pellucida
GO:0007341 penetration of zona pellucida
GO:0008285 negative regulation of cell proliferation
GO:0009101 glycoprotein biosynthetic process
GO:0009312 oligosaccharide biosynthetic process
GO:0030198 extracellular matrix organization
GO:0030879 mammary gland development
GO:0042060 wound healing
GO:0042127 regulation of cell proliferation
GO:0043065 positive regulation of apoptotic process
GO:0045136 development of secondary sexual characteristics
GO:0048754 branching morphogenesis of an epithelial tube
GO:0050900 leukocyte migration
GO:0051270 regulation of cellular component movement
GO:0060046 regulation of acrosome reaction
GO:0060054 positive regulation of epithelial cell proliferation involved in wound healing
GO:0060055 angiogenesis involved in wound healing
GO:0060058 positive regulation of apoptotic process involved in mammary gland involution
GO:0003831 beta-N-acetylglucosaminylglycopeptide beta-1,4-galactosyltransferase activity
GO:0003945 N-acetyllactosamine synthase activity
GO:0004461 lactose synthase activity
GO:0005515 protein binding
GO:0008092 cytoskeletal protein binding
GO:0008378 galactosyltransferase activity
GO:0016740 transferase activity
GO:0016757 transferase activity, transferring glycosyl groups
GO:0030145 manganese ion binding
GO:0035250 UDP-galactosyltransferase activity
GO:0042803 protein homodimerization activity
GO:0043014 alpha-tubulin binding
GO:0046872 metal ion binding
GO:0048487 beta-tubulin binding
GO:0000138 Golgi trans cisterna
GO:0005576 extracellular region
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0009897 external side of plasma membrane
GO:0009986 cell surface
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016323 basolateral plasma membrane
GO:0030057 desmosome
GO:0030112 glycocalyx
GO:0031526 brush border membrane
GO:0032580 Golgi cisterna membrane |
| Organisms for which functions have been demonstrated | Bos taurus (cow, a mammal) |
| Sequence length | 402 |
| FASTA sequence | >sp|P08037|B4GT1_BOVIN Beta-1,4-galactosyltransferase 1 OS=Bos taurus GN=B4GALT1 PE=1 SV=3
MKFREPLLGGSAAMPGASLQRACRLLVAVCALHLGVTLVYYLAGRDLRRLPQLVGVHPPLQGSSHGAAAIGQPSGELRLRGVAPPPPLQNSSKPRSRAPSNLDAYSHPGPGPGPGSNLTSAPVPSTTTRSLTACPEESPLLVGPMLIEFNIPVDLKLVEQQNPKVKLGGRYTPMDCISPHKVAIIIPFRNRQEHLKYWLYYLHPILQRQQLDYGIYVINQAGESMFNRAKLLNVGFKEALKDYDYNCFVFSDVDLIPMNDHNTYRCFSQPRHISVAMDKFGFSLPYVQYFGGVSALSKQQFLSINGFPNNYWGWGGEDDDIYNRLAFRGMSVSRPNAVIGKCRMIRHSRDKKNEPNPQRFDRIAHTKETMLSDGLNSLTYMVLEVQRYPLYTKITVDIGTPS
|
| Structure Information |
| PDB ID | 1FR8,
1FGX,
1NF5,
1NKH,
1NQI,
1NWG,
1O23,
1OQM,
1NMM,
1O0R,
1YRO,
1TVY,
1TW1,
1TW5,
2FYC,
4KRV,
1PZY,
1PZT,
2FYD,
1NHE |
| Quaternary structure | |
| SCOP | Nucleotide-diphospho-sugar transferases |
| CATH | 3.90.550.10 |
| TM Helix Prediction | 1(21-43) type II transmembrane protein |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-13, 58-128, 401-402 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Lactose synthetase, enzyme
UDP-alpha-D-galactose + D-glucose => UDP + lactose
|
| References for function | |
| E.C. number | 2.4.1.22 |
| Location of functional site(s) | |
| Cellular location of function | Golgi apparatus |
| Comments | |
| Function 2 |
| Function description | UDP-galactose: N-acetylglucosamine galactosyltransferase, enzyme
UDP-alpha-D-galactose + N-acetyl-D-glucosamine => UDP + N-acetyllactosamine |
| References for function | Brew K, Vanaman TC, Hill RL. The role of alpha-lactalbumin and the A protein in lactose synthetase: a unique mechanism for the control of a biological reaction. Proc Natl Acad Sci U S A. 1968 Feb;59(2):491-7.
PMID: 5238979 |
| E.C. number | 2.4.1.90 |
| Location of functional site(s) | |
| Cellular location of function | Golgi apparatus |
| Comments | |