| General Information |
| MoonProt ID | 290 |
| First appeared in release | 1.0 |
| Name(s) | Mitochondrial ribonuclease P protein 1
Mitochondrial RNase P protein 1
HBV pre-S2 trans-regulated protein 2
RNA (guanine-9-)-methyltransferase domain-containing protein 1
Renal carcinoma antigen NY-REN-49
tRNA methyltransferase 10 homolog C
Gene Name:TRMT10C |
| UniProt ID | Q7L0Y3 (MRRP1_HUMAN), Reviewed |
| GO terms | GO:0000964 mitochondrial RNA 5'-end processing
GO:0008033 tRNA processing
GO:0032259 methylation
GO:0005515 protein binding
GO:0008168 methyltransferase activity
GO:0016740 transferase activity
GO:0044822 poly(A) RNA binding
GO:0005739 mitochondrion
GO:0042645 mitochondrial nucleoid |
| Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal, OMIM number 615423 Combined oxidative phosphorylation deficiency 30) |
| Sequence length | |
| FASTA sequence | >sp|Q7L0Y3|MRRP1_HUMAN Mitochondrial ribonuclease P protein 1 OS=Homo sapiens GN=TRMT10C PE=1 SV=2
MAAFLKMSVSVNFFRPFTRFLVPFTLHRKRNNLTILQRYMSSKIPAVTYPKNESTPPSEELELDKWKTTMKSSVQEECVSTISSSKDEDPLAATREFIEMWRLLGREVPEHITEEELKTLMECVSNTAKKKYLKYLYTKEKVKKARQIKKEMKAAAREEAKNIKLLETTEEDKQKNFLFLRLWDRNMDIAMGWKGAQAMQFGQPLVFDMAYENYMKRKELQNTVSQLLESEGWNRRNVDPFHIYFCNLKIDGALHRELVKRYQEKWDKLLLTSTEKSHVDLFPKDSIIYLTADSPNVMTTFRHDKVYVIGSFVDKSMQPGTSLAKAKRLNLATECLPLDKYLQWEIGNKNLTLDQMIRILLCLKNNGNWQEALQFVPKRKHTGFLEISQHSQEFINRLKKAKT
|
| Structure Information |
| PDB ID | 5NFJ |
| Quaternary structure | |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-10, 43-63, 69-90, 146-177, 388-403 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Mitochondrial ribonuclease P protein 1, noncatalytic subunit
cleaves tRNA molecules in their 5'-ends
subunit of ribonuclease P, not catalytic subunit for this function
required for ribonuclease P activity
|
| References for function | Vilardo E1, Nachbagauer C, Buzet A, Taschner A, Holzmann J, Rossmanith W. A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase--extensive moonlighting in mitochondrial tRNA biogenesis. Nucleic Acids Res. 2012 Dec;40(22):11583-93. doi: 10.1093/nar/gks910.
PMID:
23042678
|
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | mitochondrion |
| Comments | |
| Function 2 |
| Function description | tRNA methyltransferase, enzyme
|
| References for function | Vilardo E, Nachbagauer C, Buzet A, Taschner A, Holzmann J, Rossmanith W. A subcomplex of human mitochondrial RNase P is a bifunctional methyltransferase--extensive moonlighting in mitochondrial tRNA biogenesis. Nucleic Acids Res. 2012 Dec;40(22):11583-93. doi: 10.1093/nar/gks910.
PMID: 23042678 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | mitochondrion |
| Comments | |