| General Information |
| MoonProt ID | 291 |
| First appeared in release | 1.0 |
| Name(s) | Zuotin
DnaJ-related protein ZUO1
J protein ZUO1
Heat shock protein 40 homolog ZUO1
Ribosome-associated complex subunit ZUO1
Gene Name: ZUO1 |
| UniProt ID | P32527 (ZUO1_YEAST), Reviewed |
| GO terms | GO:0000054 ribosomal subunit export from nucleus
GO:0006364 rRNA processing
GO:0006450 regulation of translational fidelity
GO:0006452 translational frameshifting
GO:0006457 protein folding
GO:0003677 DNA binding
GO:0005515 protein binding
GO:0051082 unfolded protein binding
GO:0005730 nucleolus
GO:0005737 cytoplasm |
| Organisms for which functions have been demonstrated | Saccharomyces cerevisiae (yeast, fungi) |
| Sequence length | 433 |
| FASTA sequence | >sp|P32527|ZUO1_YEAST Zuotin OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=ZUO1 PE=1 SV=1
MFSLPTLTSDITVEVNSSATKTPFVRRPVEPVGKFFLQHAQRTLRNHTWSEFERIEAEKNVKTVDESNVDPDELLFDTELADEDLLTHDARDWKTADLYAAMGLSKLRFRATESQIIKAHRKQVVKYHPDKQSAAGGSLDQDGFFKIIQKAFETLTDSNKRAQYDSCDFVADVPPPKKGTDYDFYEAWGPVFEAEARFSKKTPIPSLGNKDSSKKEVEQFYAFWHRFDSWRTFEFLDEDVPDDSSNRDHKRYIERKNKAARDKKKTADNARLVKLVERAVSEDPRIKMFKEEEKKEKERRKWEREAGARAEAEAKAKAEAEAKAKAESEAKANASAKADKKKAKEAAKAAKKKNKRAIRNSAKEADYFGDADKATTIDEQVGLIVDSLNDEELVSTADKIKANAAGAKEVLKESAKTIVDSGKLPSSLLSYFV
|
| Structure Information |
| PDB ID | 2LWX |
| Quaternary structure | |
| SCOP | NA |
| CATH | 1.10.8.840 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-14, 44-81, 136, 257-262, 293-350, 423-433 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | component of a chaperone complex
component of the ribosome-associated complex (RAC) that helps in folding of nascent polypeptide chains |
| References for function | |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | activator of a transcription factor
activates Pdr1 transcription factor
|
| References for function | Ducett JK, Peterson FC, Hoover LA, Prunuske AJ, Volkman BF, Craig EA. Unfolding of the C-terminal domain of the J-protein Zuo1 releases autoinhibition and activates Pdr1-dependent transcription. J Mol Biol. 2013 Jan 9;425(1):19-31. doi: 10.1016/j.jmb.2012.09.020.
PMID: 23036859 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | nucleus |
| Comments | |