| General Information |
| MoonProt ID | 297 |
| First appeared in release | 4.0 |
| Name(s) | epidermal growth factor receptor |
| UniProt ID | P00533 |
| GO terms | GO:1900087 positive regulation of G1/S transition of mitotic cell cycle
GO:0007166 cell surface receptor signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008284 positive regulation of cell population proliferation
GO:0038134 ERBB2-EGFR signaling pathway
GO:0005768 endosome
GO:0005006 epidermal growth factor receptor activity
GO:0000166 nucleotide binding
GO:0001618 virus receptor activity
GO:0003682 chromatin binding
GO:0003690 double-stranded DNA binding
GO:0004672 protein kinase activity
GO:0004709 MAP kinase kinase kinase activity
GO:0004714 transmembrane receptor protein tyrosine kinase activity
GO:0004888 transmembrane signaling receptor activity
GO:0005006 epidermal growth factor receptor activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0019899 enzyme binding
GO:0019900 kinase binding
GO:0019903 protein phosphatase binding
GO:0030296 protein tyrosine kinase activator activity
GO:0031625 ubiquitin protein ligase binding
GO:0042802 identical protein binding
GO:0045296 cadherin binding
GO:0048408 epidermal growth factor binding
GO:0051015 actin filament binding
GO:0051117 ATPase binding
GO:0000165 MAPK cascade
GO:0001503 ossification
GO:0001934 positive regulation of protein phosphorylation
GO:0007165 signal transduction
GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0007611 learning or memory
GO:0008284 positive regulation of cell population proliferation
GO:0030182 neuron differentiation
GO:0030307 positive regulation of cell growth
GO:0030335 positive regulation of cell migration
GO:0033138 positive regulation of peptidyl-serine phosphorylation
GO:0034165 positive regulation of toll-like receptor 9 signaling pathway
GO:0038134 ERBB2-EGFR signaling pathway
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042177 negative regulation of protein catabolic process
GO:0042327 positive regulation of phosphorylation
GO:0043066 negative regulation of apoptotic process
GO:0043410 positive regulation of MAPK cascade
GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0045739 positive regulation of DNA repair
GO:0045740 positive regulation of DNA replication
GO:0045944 positive regulation of transcription by RNA polymerase II
GO:0046718 symbiont entry into host cell
GO:0048146 positive regulation of fibroblast proliferation
GO:0050679 positive regulation of epithelial cell proliferation
GO:0050730 regulation of peptidyl-tyrosine phosphorylation
GO:0051205 protein insertion into membrane
GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0070141 response to UV-A
GO:0070374 positive regulation of ERK1 and ERK2 cascade
GO:0071230 cellular response to amino acid stimulus
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0071392 cellular response to estradiol stimulus
GO:0090037 positive regulation of protein kinase C signaling
GO:0090263 positive regulation of canonical Wnt signaling pathway
GO:0098609 cell-cell adhesion
GO:1902895 positive regulation of miRNA transcription
GO:1903078 positive regulation of protein localization to plasma membrane
GO:1905208 negative regulation of cardiocyte differentiation
GO:0005886 plasma membrane
GO:0009925 basal plasma membrane
GO:0031901 early endosome membrane
GO:0032587 ruffle membrane
GO:0000139 Golgi membrane
GO:0005576 extracellular region
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0005789 endoplasmic reticulum membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0005925 focal adhesion
GO:0009986 cell surface
GO:0010008 endosome membrane
GO:0016020 membrane
GO:0016323 basolateral plasma membrane
GO:0030054 cell junction
GO:0030139 endocytic vesicle
GO:0030669 clathrin-coated endocytic vesicle membrane
GO:0031901 early endosome membrane
GO:0031965 nuclear membrane
GO:0045121 membrane raft
GO:0048471 perinuclear region of cytoplasm
GO:0097489 multivesicular body, internal vesicle lumen
GO:0097708 intracellular vesicle
GO:0032991 protein-containing complex
GO:0043235 receptor complex
GO:0070435 Shc-EGFR complex |
| Organisms for which functions have been demonstrated | Homo sapiens (human) |
| Sequence length | 1210 |
| FASTA sequence | >sp|P00533|EGFR_HUMAN Epidermal growth factor receptor OS=Homo sapiens OX=9606 GN=EGFR PE=1 SV=2
MRPSGTAGAALLALLAALCPASRALEEKKVCQGTSNKLTQLGTFEDHFLSLQRMFNNCEV
VLGNLEITYVQRNYDLSFLKTIQEVAGYVLIALNTVERIPLENLQIIRGNMYYENSYALA
VLSNYDANKTGLKELPMRNLQEILHGAVRFSNNPALCNVESIQWRDIVSSDFLSNMSMDF
QNHLGSCQKCDPSCPNGSCWGAGEENCQKLTKIICAQQCSGRCRGKSPSDCCHNQCAAGC
TGPRESDCLVCRKFRDEATCKDTCPPLMLYNPTTYQMDVNPEGKYSFGATCVKKCPRNYV
VTDHGSCVRACGADSYEMEEDGVRKCKKCEGPCRKVCNGIGIGEFKDSLSINATNIKHFK
NCTSISGDLHILPVAFRGDSFTHTPPLDPQELDILKTVKEITGFLLIQAWPENRTDLHAF
ENLEIIRGRTKQHGQFSLAVVSLNITSLGLRSLKEISDGDVIISGNKNLCYANTINWKKL
FGTSGQKTKIISNRGENSCKATGQVCHALCSPEGCWGPEPRDCVSCRNVSRGRECVDKCN
LLEGEPREFVENSECIQCHPECLPQAMNITCTGRGPDNCIQCAHYIDGPHCVKTCPAGVM
GENNTLVWKYADAGHVCHLCHPNCTYGCTGPGLEGCPTNGPKIPSIATGMVGALLLLLVV
ALGIGLFMRRRHIVRKRTLRRLLQERELVEPLTPSGEAPNQALLRILKETEFKKIKVLGS
GAFGTVYKGLWIPEGEKVKIPVAIKELREATSPKANKEILDEAYVMASVDNPHVCRLLGI
CLTSTVQLITQLMPFGCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAA
RNVLVKTPQHVKITDFGLAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQSDVWSY
GVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYMIMVKCWMIDADSRPK
FRELIIEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADEYLIPQ
QGFFSSPSTSRTPLLSSLSATSNNSTVACIDRNGLQSCPIKEDSFLQRYSSDPTGALTED
SIDDTFLPVPEYINQSVPKRPAGSVQNPVYHNQPLNPAPSRDPHYQDPHSTAVGNPEYLN
TVQPTCVNSTFDSPAHWAQKGSHQISLDNPDYQQDFFPKEAKPNGIFKGSTAENAEYLRV
APQSSEFIGA |
| Structure Information |
| PDB ID | 1IVO, 1M14, 1M17 |
| Quaternary structure | monomer, dimer |
| SCOP | |
| CATH | |
| TM Helix Prediction | |
| DisProt Annotation | |
| Predicted Disorder Regions | |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enzyme, receptor kinase |
| References for function | Maeda R, Tamagaki-Asahina H, Sato T, Yanagawa M, Sako Y. Threonine phosphorylation regulates the molecular assembly and signaling of EGFR in cooperation with membrane lipids. J Cell Sci. 2022 Aug 1;135(15):jcs260355. doi: 10.1242/jcs.260355. Epub 2022 Aug 5. PMID: 35791809. |
| E.C. number | 2.7.10.1 |
| Location of functional site(s) | |
| Cellular location of function | membrane |
| Comments | |
| Function 2 |
| Function description | scaffold |
| References for function | Maeda R, Tamagaki-Asahina H, Sato T, Yanagawa M, Sako Y. Threonine phosphorylation regulates the molecular assembly and signaling of EGFR in cooperation with membrane lipids. J Cell Sci. 2022 Aug 1;135(15):jcs260355. doi: 10.1242/jcs.260355. Epub 2022 Aug 5. PMID: 35791809. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | near membrane |
| Comments | |