Protein Information

General Information
MoonProt ID300
First appeared in release1.0
Name(s)Glutamine synthetase Gene Name: glnA
UniProt IDD5GYN9 (D5GYN9_LACCS), Unreviewed
GO termsGO:0006542 glutamine biosynthetic process GO:0006807 nitrogen compound metabolic process GO:0009399 nitrogen fixation GO:0000166 nucleotide binding GO:0003824 catalytic activity GO:0004356 glutamate-ammonia ligase activity GO:0005524 ATP binding GO:0016874 ligase activity GO:0005737 cytoplasm
Organisms for which functions have been demonstratedLactobacillus crispatus
Sequence length445
FASTA sequence>gi|492019134|ref|WP_005719812.1| glutamine synthetase [Lactobacillus crispatus] MSKQYTAEEIKQEVEDKDVRFLRLAFTDINGTEKAVEVPKSQLDKVLTNDIRFDGSSIDGFVRLEESDMVLYPDFSTWTVLPWGDEHGGKIGRLICSVHTTDGKPFAGDPRNNLKRVLGEMNEAGFDTFDIGFEMEFHLFKLDEDGNWTTEVPDHASYFDMTSDDEGARCRREIVETLEGMGFEVEAAHHEVGDGQQEIDFRFDDALTTADRCQTFKMVTRAIARKHGLFASFMAKPVQGQAGNGMHNNMSLFKNGKNVFYDKDGEFHLSNTALYFLNGILEHARAITAIGNPTVNSYKRLIPGFEAPVYIAWAAKNRSPLVRIPSAGEINTRLEMRSADPTANPYLLLAACLTAGLNGIKEQKMPMKPVEENIFEMTEEERAEHGIKPLPTTLHNAIKAFKKDDLIKSSLGDHLMHSFIESKELEWSKYSQSVSDWERQRYMNW
Structure Information
PDB ID
Quaternary structure
Function 1
Function descriptionGlutamine synthetase, enzyme ATP + L-glutamate + NH3 => ADP + phosphate + L-glutamine
References for function
E.C. number6.3.1.2
Location of functional site(s)
Cellular location of functioncytoplasm
Comments
Function 2
Function descriptionfibronectin, laminin, collagen I binding, and plasminogen binding
References for functionKainulainen V, Loimaranta V, Pekkala A, Edelman S, Antikainen J, Kylvj R, Laaksonen M, Laakkonen L, Finne J, Korhonen TK. (2012) Glutamine synthetase and glucose-6-phosphate isomerase are adhesive moonlighting proteins of Lactobacillus crispatus released by epithelial cathelicidin LL-37. J Bacteriol. 2012 May;194(10):2509-19. doi: 10.1128/JB.06704-11. Epub 2012 Mar 2. PMID: 22389474
E.C. number
Location of functional site(s)
Cellular location of functioncell surface
Comments