| General Information |
| MoonProt ID | 300 |
| First appeared in release | 1.0 |
| Name(s) | Glutamine synthetase
Gene Name: glnA |
| UniProt ID | D5GYN9 (D5GYN9_LACCS), Unreviewed |
| GO terms | GO:0006542 glutamine biosynthetic process
GO:0006807 nitrogen compound metabolic process
GO:0009399 nitrogen fixation
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0004356 glutamate-ammonia ligase activity
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0005737 cytoplasm |
| Organisms for which functions have been demonstrated | Lactobacillus crispatus (Gram positive bacterium) |
| Sequence length | 445 |
| FASTA sequence | >gi|492019134|ref|WP_005719812.1| glutamine synthetase [Lactobacillus crispatus]
MSKQYTAEEIKQEVEDKDVRFLRLAFTDINGTEKAVEVPKSQLDKVLTNDIRFDGSSIDGFVRLEESDMVLYPDFSTWTVLPWGDEHGGKIGRLICSVHTTDGKPFAGDPRNNLKRVLGEMNEAGFDTFDIGFEMEFHLFKLDEDGNWTTEVPDHASYFDMTSDDEGARCRREIVETLEGMGFEVEAAHHEVGDGQQEIDFRFDDALTTADRCQTFKMVTRAIARKHGLFASFMAKPVQGQAGNGMHNNMSLFKNGKNVFYDKDGEFHLSNTALYFLNGILEHARAITAIGNPTVNSYKRLIPGFEAPVYIAWAAKNRSPLVRIPSAGEINTRLEMRSADPTANPYLLLAACLTAGLNGIKEQKMPMKPVEENIFEMTEEERAEHGIKPLPTTLHNAIKAFKKDDLIKSSLGDHLMHSFIESKELEWSKYSQSVSDWERQRYMNW |
| Structure Information |
| PDB ID | closest is bacillus at 53% amino acid sequence identity |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1--6 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Glutamine synthetase, enzyme
ATP + L-glutamate + NH3 => ADP + phosphate + L-glutamine |
| References for function | |
| E.C. number | 6.3.1.2 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | fibronectin, laminin, collagen I binding, and plasminogen binding |
| References for function | Kainulainen V, Loimaranta V, Pekkala A, Edelman S, Antikainen J, Kylvj R, Laaksonen M, Laakkonen L, Finne J, Korhonen TK. (2012) Glutamine synthetase and glucose-6-phosphate isomerase are adhesive moonlighting proteins of Lactobacillus crispatus released by epithelial cathelicidin LL-37. J Bacteriol. 2012 May;194(10):2509-19. doi: 10.1128/JB.06704-11. Epub 2012 Mar 2.
PMID: 22389474 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |