General Information |
MoonProt ID | 305 |
First appeared in release | 2.0 |
Name(s) | aldolase A, fructose-1,6-bisphosphate (fru 1,6?P2) aldolase, Fructose-bisphosphate aldolase A
Gene: ALDOA |
UniProt ID | P00883 (ALDOA_RABIT) |
GO terms | GO:0006096 glycolytic process
GO:0051289 protein homotetramerization
GO:0003824 catalytic activity
GO:0004332 fructose-bisphosphate aldolase activity
GO:0005515 protein binding
GO:0016829 lyase activity
GO:0005737 cytoplasm
GO:0031430 M band
GO:0031674 I band |
Organisms for which functions have been demonstrated | Oryctolagus cuniculus (Rabbit. a mammal) |
Sequence length | 364 amino acids |
FASTA sequence | >sp|P00883|ALDOA_RABIT Fructose-bisphosphate aldolase A OS=Oryctolagus cuniculus GN=ALDOA PE=1 SV=2
MPHSHPALTPEQKKELSDIAHRIVAPGKGILAADESTGSIAKRLQSIGTENTEENRRFYRQLLLTADDRVNPCIGGVILFHETLYQKADDGRPFPQVIKSKGGVVGIKVDKGVVPLAGTNGETTTQGLDGLSERCAQYKKDGADFAKWRCVLKIGEHTPSALAIMENANVLARYASICQQNGIVPIVEPEILPDGDHDLKRCQYVTEKVLAAVYKALSDHHIYLEGTLLKPNMVTPGHACTQKYSHEEIAMATVTALRRTVPPAVTGVTFLSGGQSEEEASINLNAINKCPLLKPWALTFSYGRALQASALKAWGGKKENLKAAQEEYVKRALANSLACQGKYTPSGQAGAAASESLFISNHAY |
Structure Information |
PDB ID | 1ZAH, 3B8D, 1EWE, 2QUU, 3DFN, 6ALD, 3DFQ, 1EX5, 1ADO, 1EWD |
Quaternary structure | |
SCOP | TIM beta/alpha-barrel |
CATH | 3.20.20.70 |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | 1-11, 344-355, 362-364 |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | aldolase, cleavage of carbon-carbon bonds, in glycolysis, gluconeogenesis, and fructose metabolism, D-fructose 1,6-bisphosphate => dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate. |
References for function | Ritterson Lew C, Tolan DR. 2013. Aldolase sequesters WASP and affects. WASP/Arp2/3-stimulated actin dynamics. J Cell Biochem 114:1928-1939. PMID: 23495010 |
E.C. number | 4.1.2.13 |
Location of functional site(s) | cytoplasm |
Cellular location of function | |
Comments | |
Function 2 |
Function description | sequesters WASP, Wiskott–Aldrich Syndrome Protein, which is involved in controlling actin dynamics, inihibits actin polymerization, only binds to active from of WASP, inhibits WA?stimulated Arp2/3?dependent actin?polymerization reaction |
References for function | Ritterson Lew C, Tolan DR. 2013. Aldolase sequesters WASP and affects. WASP/Arp2/3-stimulated actin dynamics. J Cell Biochem 114:1928-1939. PMID: 23495010 |
E.C. number | |
Location of functional site(s) | direct binding of aldolase to the acidic portion of the WA domain |
Cellular location of function | cytoplasm |
Comments | used mutations that knock out either catalytic activity or actin binding to show the two functions were separable, Ritterson Lew C, Tolan DR. 2013. Aldolase sequesters WASP and affects. WASP/Arp2/3-stimulated actin dynamics. J Cell Biochem 114:1928-1939. PMID: 23495010 |