Protein Information

General Information
MoonProt ID309
First appeared in release2.0
Name(s)ask1, Gene: GSTUMT00005863001
UniProt IDD5GCF2 (D5GCF2_TUBMM)
GO termsGO:0008608 attachment of spindle microtubules to kinetochore GO:0000778 condensed nuclear chromosome kinetochore GO:0005634 nucleus GO:0005829 cytosol GO:0042729 DASH complex GO:0044732 mitotic spindle pole body GO:0072686 mitotic spindle
Organisms for which functions have been demonstratedTuber melanosporum
Sequence length410 amino acids
FASTA sequence>tr|D5GCF2|D5GCF2_TUBMM Uncharacterized protein OS=Tuber melanosporum (strain Mel28) GN=GSTUM_00005863001 PE=4 SV=1 MSRPPLSLTAELEKLEQSITLTLQEIDHNFSKAHRIVTTSIIPIVERYAKESEAVWEGSKFWKQFFEASANVALSNYQEEEETYEETGVATNAETYITASSPGNYGEQSTRITQEDDPRHRETQWENIESPFDALRKDDDADMTFEPTLLPATPQTSRRTRPAKGSFETPKSSPFYPSAAGAIGKKTPGGANEDQLLHRVLDKNWRLQATPLGKPPPSRYRTIGAATATTPKAQILPPPGSESPMSSPPKPHFYSADIFSSPIPGFGGFDGGKKPKPSTTSNTTVLAGDPKTPISRRYGTAKVTTTHHHELSQQGDEGRFAYGYDDDDDSDDLDLPPGLSPPVTIQFSLPPSKLLATPAREASRRIVHDILQTAGAADESGATGGSSPPVVRDVGPLDDTF
Structure Information
PDB IDNone, closest homologue to Chain A, Ask1 [Chaetomium thermophilum] 75.68% 6CFZ
Quaternary structure
SCOPNA
CATHNA
TM Helix Predictionno TM helices
DisProt AnnotationNot in DisProt
Predicted Disorder Regions1-10, 30-65, 199-218, 243-251
Connections to Disease
OMIM ID
Function 1
Function descriptionpart of DASH complex, which binds to microtubules and kinetochores and regulates their association
References for function
E.C. number
Location of functional site(s)cytoplasm
Cellular location of function
Comments
Function 2
Function descriptiontranscriptional regulator
References for functionMontanini B, Levati E, Bolchi A, Kohler A, Morin E, Tisserant E, Martin F, Ottonello S. Genome-wide search and functional identification of transcription factors in the mycorrhizal fungus Tuber melanosporum. New Phytol. 2011 Feb;189(3):736-50. doi: 10.1111/j.1469-8137.2010.03525.x. PMID: 21058951.
E.C. number
Location of functional site(s)
Cellular location of functionnucleus
Comments