| General Information |
| MoonProt ID | 311 |
| First appeared in release | 2.0 |
| Name(s) | beta-arrestin-2, Gene: ARRB2 |
| UniProt ID | P32121 (ARRB2_HUMAN) |
| GO terms | GO:0001932 regulation of protein phosphorylation
GO:0001934 positive regulation of protein phosphorylation
GO:0002031 G-protein coupled receptor internalization
GO:0002032 desensitization of G-protein coupled receptor protein signaling pathway by arrestin
GO:0002092 positive regulation of receptor internalization
GO:0006366 transcription from RNA polymerase II promoter
GO:0006810 transport
GO:0006897 endocytosis
GO:0007165 signal transduction
GO:0007179 transforming growth factor beta receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007212 dopamine receptor signaling pathway
GO:0007420 brain development
GO:0007628 adult walking behavior
GO:0008277 regulation of G-protein coupled receptor protein signaling pathway
GO:0009968 negative regulation of signal transduction
GO:0015031 protein transport |
| Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal) |
| Sequence length | 409 amino acids |
| FASTA sequence | >sp|P32121|ARRB2_HUMAN Beta-arrestin-2 OS=Homo sapiens GN=ARRB2 PE=1 SV=2
MGEKPGTRVFKKSSPNCKLTVYLGKRDFVDHLDKVDPVDGVVLVDPDYLKDRKVFVTLTCAFRYGREDLDVLGLSFRKDLFIATYQAFPPVPNPPRPPTRLQDRLLRKLGQHAHPFFFTIPQNLPCSVTLQPGPEDTGKACGVDFEIRAFCAKSLEEKSHKRNSVRLVIRKVQFAPEKPGPQPSAETTRHFLMSDRSLHLEASLDKELYYHGEPLNVNVHVTNNSTKTVKKIKVSVRQYADICLFSTAQYKCPVAQLEQDDQVSPSSTFCKVYTITPLLSDNREKRGLALDGKLKHEDTNLASSTIVKEGANKEVLGILVSYRVKVKLVVSRGGDVSVELPFVLMHPKPHDHIPLPRPQSAAPETDVPVDTNLIEFDTNYATDDDIVFEDFARLRLKGMKDDDYDDQLC |
| Structure Information |
| PDB ID | None, 76.74% similarity with Chain A, Beta-arrestin-1 [Homo sapiens], but 97.71% similarity with Chain A, Beta-arrestin-2 [Bos taurus] 5TV1 |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-7, 95, 178-183, 350-370, 399-409 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | uncouple activated seven-transmembrane receptors from heterotrimeric G proteins, mediate the endocytosis of most G-protein-coupled receptors (GPCRs) |
| References for function | |
| E.C. number | |
| Location of functional site(s) | cytoplasm |
| Cellular location of function | |
| Comments | |
| Function 2 |
| Function description | regulates transcription
|
| References for function | Neuhaus EM, Mashukova A, Barbour J, Wolters D, Hatt H. Novel function of beta-arrestin2 in the nucleus of mature spermatozoa. J Cell Sci. 2006 Aug 1;119(Pt 15):3047-56. PMID: 16820410. |
| E.C. number | |
| Location of functional site(s) | nucleus |
| Cellular location of function | |
| Comments | |