Protein Information

General Information
MoonProt ID312
First appeared in release2.0
Name(s)C5a peptidase, Streptococcal C5a peptidase, Gene: ScpB
UniProt IDQ8E4T9 (Q8E4T9_STRA3)
GO termsGO:0006508 proteolysis GO:0004252 serine-type endopeptidase activity GO:0008233 peptidase activity GO:0008236 serine-type peptidase activity GO:0016787 hydrolase activity GO:0005618 cell wall GO:0016020 membrane GO:0016021 integral component of membrane
Organisms for which functions have been demonstratedStreptococcus agalactiae, group B streptococci (GBS)
Sequence length1150 amino acids
FASTA sequence>tr|Q8E4T9|Q8E4T9_STRA3 Streptococcal C5a peptidase OS=Streptococcus agalactiae serotype III (strain NEM316) GN=scpB PE=3 SV=1 MRKKQKLPFDKLAIALMSTSILLNAQSDIKANTVTEDTPATEQTVETPQPTAVSEEAPSSKETKTPQTPSDAGETVADDANDLAPQAPAKTADTPATSKATIRDLNDPSQVKTLQEKAGKGAGTVVAVIDAGFDKNHEAWRLTDKAKARYQSKEDLEKAKKEHGITYGEWVNDKVAYYHDYSKDGKTAVDQEHGTHVSGILSGNAPSETKEPYRLEGAMPEAQLLLMRVEIVNGLADYARNYAQAIRDAINLGAKVINMSFGNAALAYANLPDETKKAFDYAKSKGVSIVTSAGNDSSFGGKTRLPLADHPDYGVVGTPAAADSTLTVASYSPDKQLTETATVKTADQQDKEMPVLSTNRFEPNKAYDYAYANRGTKEDDFKDVKGKIALIERGDIDFKDKIAKAKKAGAVGVLIYDNQDKGFPIELPNVDQMPAAFISRKDGLLLKDNPQKTITFNATPKVLPTASGTKLSRFSSWGLTADGNIKPDIAAPGQDILSSVANNKYAKLSGTSMSAPLVAGIMGLLQKQYETQYPDMTPSERLDLAKKVLMSSATALYDEDEKAYFSPRQQGAGAVDAKKASAATMYVTDKDNTSSKVHLNNVSDKFEVTVTVHNKSDKPQELYYQATVQTDKVDGKHFALAPKALYETSWQKITIPANSS
Structure Information
PDB IDNone, but some structures from very close homologues are available
Quaternary structure
Function 1
Function descriptionprotease, peptidase, endopeptidase, cleaves and inactivates C5a (a component of the human complement system), helps GBS evade phagocytosis
References for function
E.C. number
Location of functional site(s)
Cellular location of functioncell surface
Comments
Function 2
Function descriptionfibronectin binding, adhesin
References for functionBeckmann C, Waggoner JD, Harris TO, Tamura GS, Rubens CE: Identification of novel adhesins from Group B streptococci by use of phage display reveals that C5a peptidase mediates fibronectin binding. Infect Immun 2002, 70(6):2869-2876. PMID: 12010974.
E.C. number
Location of functional site(s)
Cellular location of functioncell surface
Comments