| General Information |
| MoonProt ID | 313 |
| First appeared in release | 2.0 |
| Name(s) | CALM, Phosphatidylinositol-binding clathrin assembly protein, Gene: PICALM |
| UniProt ID | Q13492 (PICAL_HUMAN) |
| GO terms | GO:0006461 protein complex assembly
GO:0006897 endocytosis
GO:0006898 receptor-mediated endocytosis
GO:0008283 cell proliferation
GO:0010629 negative regulation of gene expression
GO:0016188 synaptic vesicle maturation
GO:0016192 vesicle-mediated transport
GO:0016197 endosomal transport
GO:0030100 regulation of endocytosis
GO:0031623 receptor internalization
GO:0032880 regulation of protein localization
GO:0035459 cargo loading into vesicle
GO:0045893 positive regulation of transcription, DNA-templated
GO:0048261 negative regulation of receptor-mediated endocytosis
GO:0048268 clathrin coat assembly
GO:0055072 iron ion homeostasis
GO:0072583 clathrin-mediated endocytosis
GO:0097459 iron ion import into cell
GO:1901216 positive regulation of neuron death
GO:1902004 positive regulation of beta-amyloid formation
GO:1902959 regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902961 positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
GO:1902963 negative regulation of metalloendopeptidase activity involved in amyloid precursor protein catabolic process
GO:0005515 protein binding
GO:0005543 phospholipid binding
GO:0005545 1-phosphatidylinositol binding
GO:0030276 clathrin binding
GO:0032050 clathrin heavy chain binding
GO:0035615 clathrin adaptor activity
GO:0005634 nucleus
GO:0005794 Golgi apparatus
GO:0005905 coated pit
GO:0005905 coated pit
GO:0016020 membrane
GO:0030136 clathrin-coated vesicle
GO:0031410 cytoplasmic vesicle
GO:0031982 vesicle
GO:0042734 presynaptic membrane
GO:0043025 neuronal cell body
GO:0045211 postsynaptic membrane
GO:0097418 neurofibrillary tangle
GO:0030122 AP-2 adaptor complex
GO:0030132 clathrin coat of coated pit
GO:0048471 perinuclear region of cytoplasm |
| Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal) |
| Sequence length | 652 amino acids |
| FASTA sequence | >sp|Q13492|PICAL_HUMAN Phosphatidylinositol-binding clathrin assembly protein OS=Homo sapiens GN=PICALM PE=1 SV=2
MSGQSLTDRITAAQHSVTGSAVSKTVCKATTHEIMGPKKKHLDYLIQCTNEMNVNIPQLADSLFERTTNSSWVVVFKSLITTHHLMVYGNERFIQYLASRNTLFNLSNFLDKSGLQGYDMSTFIRRYSRYLNEKAVSYRQVAFDFTKVKRGADGVMRTMNTEKLLKTVPIIQNQMDALLDFNVNSNELTNGVINAAFMLLFKDAIRLFAAYNEGIINLLEKYFDMKKNQCKEGLDIYKKFLTRMTRISEFLKVAEQVGIDRGDIPDLSQAPSSLLDALEQHLASLEGKKIKDSTAASRATTLSNAVSSLASTGLSLTKVDEREKQAALEEEQARLKALKEQRLKELAKKPHTSLTTAASPVSTSAGGIMTAPAIDIFSTPSSSNSTSKLPNDLLDLQQPTFHPSVHPMSTASQVASTWGDPFSATVDAVDDAIPSLNPFLTKSSGDVHLSISSDVSTFTTRTPTHEMFVGFTPSPVAQPHPSAGLNVDFESVFGNKSTNVIVDSGGFDELGGLLKPTVASQNQNLPVAKLPPSKLVSDDLDSSLANLVGNLGIGNGTTKNDVNWSQPGEKKLTGGSNWQPKVAPTTAWNAATMAPPVMAYPATTPTGMIGYGIPPQMGSVPVMTQPTLIYSQPVMRPPNPFGPVSGAQIQFM |
| Structure Information |
| PDB ID | 1HF8, 3ZYK, 3ZYM, 3ZYL |
| Quaternary structure | |
| SCOP | Spectrin repeat-like, alpha-alpha superhelix |
| CATH | 1.25.40.90, 1.20.58.150 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-15, 147-159, 284-370, 378-391, 394-427, 429-485, 497-506, 516-532, 554-608, 613-617, 630-636, 639-652 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | binds clathrin in endocytosis, assembly protein helps bring clathrin and adapter protein complex 2 (AP2) to cell membranes at sites of coated-pit formation and clathrin-vesicle assembly |
| References for function | 10436022 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | transcription activation |
| References for function | Vecchi M, Polo S, Poupon V, van de Loo JW, Benmerah A, Di Fiore PP. Nucleocytoplasmic shuttling of endocytic proteins. J Cell Biol. 2001 Jun 25;153(7):1511-7. PMID: 11425879. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | nucleus |
| Comments | |