| General Information |
| MoonProt ID | 314 |
| First appeared in release | 2.0 |
| Name(s) | Csn7, COP9 signalosome complex subunit 7
Gene: CSN7 |
| UniProt ID | Q9V4S8 (CSN7_DROME) |
| GO terms | GO:0000338 protein deneddylation
GO:0007095 mitotic G2 DNA damage checkpoint
GO:0007275 multicellular organism development
GO:0007281 germ cell development
GO:0010388 cullin deneddylation
GO:0019233 sensory perception of pain
GO:0030154 cell differentiation
GO:0036099 female germ-line stem cell population maintenance
GO:0046331 lateral inhibition
GO:0048140 male germ-line cyst encapsulation
GO:0048142 germarium-derived cystoblast division
GO:0048477 oogenesis
GO:0050821 protein stabilization
GO:0051726 regulation of cell cycle
GO:0005515 protein binding
GO:0019781 NEDD8 activating enzyme activity
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0008180 COP9 signalosome
GO:0034399 nuclear periphery |
| Organisms for which functions have been demonstrated | Drosophila melanogaster (fruit fly, an insect) |
| Sequence length | 278 amino acids |
| FASTA sequence | >sp|Q9V4S8|CSN7_DROME COP9 signalosome complex subunit 7 OS=Drosophila melanogaster GN=CSN7 PE=1 SV=2
MTQDMLLGNEEPSKSKETFLEKFCVLAKSSTGAALLDVIRQALEAPNVFVFGELLAEPSVLQLKDGPDSKHFETLNLFAYGTYKEYRAQPEKFIELTPAMQKKLQHLTIVSLAIKAKSIPYALLLSELEIDNVRHLEDIIIEAIYADIIHGKLFQNTRILEVDYAQGRDIPPGYTGQIVETLQAWVNSCDSVSNCIEMQIKYANAEKSKRLINKERVEQDLINLKKVLKSQTSDSDESMQIDTHGPGTSGGLGQSELRKKPSKLRNPRSAAVGLKFSK |
| Structure Information |
| PDB ID | none, closest homologues has 48% amino acid sequence identity |
| Quaternary structure | part of a multiprotein complex, the COP9 signalosome |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-14, 206-278 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | part of COP9 signalosome (CSN), in ubiquitin-mediated protein degradation, CSN removes the ubiquitin-like protein Nedd8 from the cullin subunit of cullin-RING E3 ligase (CRL) |
| References for function | 25106867 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | nucleus |
| Comments | |
| Function 2 |
| Function description | |
| References for function | |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |