| General Information |
| MoonProt ID | 316 |
| First appeared in release | 2.0 |
| Name(s) | DPP4, dipeptidyl peptidase 4, Gene: DPP4 |
| UniProt ID | P27487 (DPP4_HUMAN) |
| GO terms | GO:0001662 behavioral fear response
GO:0001666 response to hypoxia
GO:0006508 proteolysis
GO:0007155 cell adhesion
GO:0008284 positive regulation of cell proliferation
GO:0010716 negative regulation of extracellular matrix disassembly
GO:0031295 T cell costimulation
GO:0033632 regulation of cell-cell adhesion mediated by integrin
GO:0035641 locomotory exploration behavior
GO:0036343 psychomotor behavior
GO:0042110 T cell activation
GO:0043542 endothelial cell migration
GO:0046718 viral entry into host cell
GO:0001618 virus receptor activity
GO:0002020 protease binding
GO:0004177 aminopeptidase activity
GO:0004252 serine-type endopeptidase activity
GO:0005102 receptor binding |
| Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal) |
| Sequence length | 766 amino acids |
| FASTA sequence | >sp|P27487|DPP4_HUMAN Dipeptidyl peptidase 4 OS=Homo sapiens GN=DPP4 PE=1 SV=2
MKTPWKVLLGLLGAAALVTIITVPVVLLNKGTDDATADSRKTYTLTDYLKNTYRLKLYSLRWISDHEYLYKQENNILVFNAEYGNSSVFLENSTFDEFGHSINDYSISPDGQFILLEYNYVKQWRHSYTASYDIYDLNKRQLITEERIPNNTQWVTWSPVGHKLAYVWNNDIYVKIEPNLPSYRITWTGKEDIIYNGITDWVYEEEVFSAYSALWWSPNGTFLAYAQFNDTEVPLIEYSFYSDESLQYPKTVRVPYPKAGAVNPTVKFFVVNTDSLSSVTNATSIQITAPASMLIGDHYLCDVTWATQERISLQWLRRIQNYSVMDICDYDESSGRWNCLVARQHIEMSTTGWVGRFRPSEPHFTLDGNSFYKIISNEEGYRHICYFQIDKKDCTFITKGTWEVIGIEALTSDYLYYISNEYKGMPGGRNLYKIQLSDYTKVTCLSCELNPERCQYYSVSFSKEAKYYQLRCSGPGLPLYTLHSSVNDKGLRVLEDNSALDKMLQNVQMPSKKLDFIILNETKFWYQMILPPHFDKSKKYPLLLDVYAGPCSQKADTVFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINRRLGTFEVEDQIEAARQFSKMGFVDNKRIAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDVGVDFQAMWYTDEDHGIASSTAHQHIYTHMSHFIKQCFSLP |
| Structure Information |
| PDB ID | 2QT9, 2BGR, and several others |
| Quaternary structure | |
| SCOP | 8-bladed beta-propeller, alpha/beta-Hydrolases |
| CATH | 3.40.50.1820, 2.140.10.30 |
| TM Helix Prediction | 1(7-29) type II transmembrane protein |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-3, 32-36, 245-247, 440-443, 448-450, 764-766 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | serine exopeptidase, dipeptidyl peptidase, regulates several physiological processes by cleaving peptides in the blood, i.e. chemokines, growth factors, neuropeptides, removes N-terminal dipeptides from proteins with unsubstituted N-termini as long as the second residue is proline |
| References for function | 10593948, 10951221 |
| E.C. number | 3.4.14.5 |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |
| Function 2 |
| Function description | glycoprotein receptor, involved in T-cell activation, binds ADA, CAV1, IGF2R, and PTPRC |
| References for function | 17287217 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |