| General Information |
| MoonProt ID | 317 |
| First appeared in release | 2.0 |
| Name(s) | DPP10, RE27507p, Gene: CG11319, GenBank NP_609051 |
| UniProt ID | Q9VMB4 (Q9VMB4_DROME) |
| GO terms | |
| Organisms for which functions have been demonstrated | Drosophila melanogaster (fruit fly, an insect) |
| Sequence length | 935 amino acids |
| FASTA sequence | >tr|Q9VMB4|Q9VMB4_DROME RE27507p OS=Drosophila melanogaster GN=CG11319 PE=2 SV=3
MPEQDNYDDELVSSNPNQRNWRGILIALLVIIIVLALIVTSVVLLTPPDEGPRVKGQRIKLQDIVDGLFVPQHSNGSWIDGEEFLYQDHLGRICLLNAANRSERVLMSNVTFKTLSPFTFTISADKRYLLLAQNVVKLFRHSYLAQYTLYDIQTSESIKLRHSPHQDEWPYLHYARFTPAGNALVWVQSYDIYYREEVRSASVHRITHDAVPGVVYNGIPDWLYEEEILHANNAIWMSDNGQLMLYATFNDTHVQEQHFAWYGTTGPSAGGAAAAAAVGAGGAGTGSPGAGGSNPHASLYPEIRSLRYPKPGTQNPTVTLRVADLKDPLKVHITDLHPPQIIANEDHYFSSASWVSHSKIAVVWLNRPQNISVVSVCKAPLFQCIETHRVSGDGRGWVDTVAVPLFAANASIYVAISPLRDGLFGYFRHIVHVDIDKNRVLPLTHGPYEVNRLLHWDQLDNWIYFLGTPERLPSQQHLYRVSALPARQGQALRSPDCLTCPAVSQWSEGYDEGHTKSPPKLVTAWDDDWEDSEEAEAQPPQPALPVEQQPPGRGQSAPLPPPPSDCLYHEAKFPISRQAKYVLIDCLGPVVPTSILYGLKSAAADSAKTKRHSTQQEEPPTEGGDEKPGEEPKSQFLELLVIVQNNTRLKEKMAKTAMPQIKTFPVMISGGYHAQVRLYLPPVLREDEITRYPTILHVYSGPGSQLVTDHWHVDWNTYLSGSKDYIVVEIDGRGSAGQGYQLLHEVYKRLGSVEVSDQLEVSEYLRDNLHFIDSRRMGVWGWSYGGYTAALALAGQQSIFQCGISVSPVTNWKLYDSTYAERYLSFPNVTDNYKGYEESDLSKYVDNLRDRQFLLVHGTADDNVHVQQSMVLARSLTSKGVLYKQQIYPDEGHSLSGVKRHLYRSMTAFFEDCFKKLVPPESKAGLGNGGDMQQQ |
| Structure Information |
| PDB ID | None, closest homologue is from Myotis davidii, 35.31% Chain A, Dipeptidyl peptidase 4 6L8Q_A |
| Quaternary structure | auxiliary protein to K+ channel |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | 1(21-43) transmembrane protein |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-15, 51-53, 268-297, 512-517, 531-561, 605-631, 830, 921-935 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enzyme, dipeptidyl peptidase activity with Gly-Pro-MCA (glycyl-L-proline 4-methylcoumaryl-7-amide) as a substrate |
| References for function | 27198182 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | mammalian homologue apparently lost enzyme activity during evolution and only has channel regulatory activity |
| Function 2 |
| Function description | ancillary subunit of Kv4 channels, bind to pore-forming subunits of voltage-gated K+ channels, causes negative shifts in voltage dependence of channel activation and steady state inactivation |
| References for function | Shiina Y, Muto T, Zhang Z, Baihaqie A, Yoshizawa T, Lee HI, Park E, Tsukiji S, Takimoto K. Fly DPP10 acts as a channel ancillary subunit and possesses peptidase activity. Sci Rep. 2016 May 20;6:26290. doi: 10.1038/srep26290. PMID: 27198182 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |