| General Information |
| MoonProt ID | 318 |
| First appeared in release | 2.0 |
| Name(s) | EF-1-alpha, 50 kDa actin-binding protein, ABP-50, Gene: eef1a1 |
| UniProt ID | P0CT31 (EF1A1_DICDI) |
| GO terms | GO:0006412 translation
GO:0006414 translational elongation
GO:0009617 response to bacterium
GO:0051017 actin filament bundle assembly
GO:0000166 nucleotide binding
GO:0003746 translation elongation factor activity
GO:0003779 actin binding
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0051015 actin filament binding
GO:0005737 cytoplasm
GO:0005938 cell cortex
GO:0030027 lamellipodium
GO:0030175 filopodium
GO:0045335 phagocytic vesicle |
| Organisms for which functions have been demonstrated | Dictyostelium discoideium (slime mold) |
| Sequence length | 453 amino acids |
| FASTA sequence | >sp|P0CT31|EF1A1_DICDI Elongation factor 1-alpha OS=Dictyostelium discoideum GN=eef1a1 PE=1 SV=1
MGKEKTHINIVVIGHVDAGKSTTTGHLIYKCGGIDKRVIEKYEKEASEMGKQSFKYAWVMDKLKAERERGITIDIALWKFETSKYYFTIIDAPGHRDFIKNMITGTSQADCAVLVIASPTGEFEAGIAKNGQTREHALLAYTLGVKQMIVAINKMDEKSTNYSQARYDEIVKEVSSFIKKIGYNPEKVAFVPISGWNGDNMLERSDKMEWYKGPTLLEALDAIVEPKRPHDKPLRIPLQDVYKIGGIGTVPVGRVETGIIKPGMVVTFAPAGLSTEVKSVEMHHEQLPEARPGDNVGFNVKNVSVKEIKRGMVAGDSKNDPPQETEKFVAQVIVLNHPGQIHAGYSPVLDCHTAHIACKFTEIVDKVDRRTGAVVAKEGTAAVVLKNGDAAMVELTPSRPMCVESFTEYPPLGRFAVRDMRQTVAVGVIKSTVKKAPGKAGDKKGAAAPSKKK |
| Structure Information |
| PDB ID | None, closest homologue is from Oryctolagus cuniculus, 74.08% Chain A, Elongation Factor 1-alpha 2 4C0S_A |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-7, 46-50, 127-128, 315-319, 371-381, 435-453 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | elongation factor |
| References for function | |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | regulate cell motility by assembling actin filament |
| References for function | Murray JW, Edmonds BT, Liu G, Condeelis J. Bundling of actin filaments by elongation factor 1 alpha inhibits polymerization at filament ends .J Cell Biol. 1996 Dec;135(5):1309-21. PMID: 8947553. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |