| General Information |
| MoonProt ID | 32 |
| First appeared in release | 1.0 |
| Name(s) | Enolase
2-phospho-D-glycerate hydro-lyase
2-phosphoglycerate dehydratase
Gene Name: eno
|
| UniProt ID | E0N8L2 (E0N8L2_NEIME), Unreviewed |
| GO terms | GO:0006096 glycolysis
GO:0000287 magnesium ion binding
GO:0004634 phosphopyruvate hydratase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0000015 phosphopyruvate hydratase complex
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0009986 cell surface |
| Organisms for which functions have been demonstrated | Neisseria meningitidis (Gram negative bacterium, causes meningitis) |
| Sequence length | 428 |
| FASTA sequence | >gi|488142178|ref|WP_002213386.1| enolase [Neisseria meningitidis]
MSAIVDIFAREILDSRGNPTVECDVLLESGVMGRAAVPSGASTGQKEALELRDGDKSRYSGKGVLKAVEHVNNQIAQALIGIDANEQSYIDQIMIELDGTENKGNLGANATLAVSMAVARAAAEDSGLPLYRYLGGAGPMSLPVPMMNVINGGEHANNSLNIQEFMIMPVGAKSFREALRCGAEIFHALKKLCDSKGFPTTVGDEGGFAPNLNSHKEALQLMVEATEAVGYKAGEDVLFALDCASSEFYKDGKYHLEAEGRSYTNAEFAEYLESLVNEFPIISIEDGMDENDWEGWKLLTEKLGGKVQLVGDDLFVTNPKILAEGIEKGVANALLVKVNQIGTLSETLKAVDLAKRNRYASVMSHRSGETEDSTIADLAVATNCMQIKTGSLSRSDRMAKYNQLLRIEEELAEAAYYPGKAAFYQLGK |
| Structure Information |
| PDB ID | Closest homologue is 4A3R (67.21%) |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-3,41-43, 424-428 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Enolase
2-phospho-D-glycerate => phosphoenolpyruvate + H2O.
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate
Carbohydrate degradation, glycolysis |
| References for function | |
| E.C. number | 4.2.1.11 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | plasminogen binding |
| References for function | Knaust A, Weber MV, Hammerschmidt S, Bergmann S, Frosch M, Kurzai O. (2007) Cytosolic proteins contribute to surface plasminogen recruitment of Neisseria meningitidis. J Bacteriol. 189(8):3246-55.Epub 2007 Feb 16. PMID: 17307854 |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |