| General Information |
| MoonProt ID | 321 |
| First appeared in release | 2.0 |
| Name(s) | elongation factor 1alpha, EF-1alpha, Elongation factor 1-alpha 1, EF-1-alpha-1, Elongation factor Tu, EF-Tu, Eukaryotic elongation factor 1 A-1, eEF1A-1, Gene: EEF1A1 |
| UniProt ID | P68105 (EF1A1_RABIT) |
| GO terms | GO:0006412 translation
GO:0006414 translational elongation
GO:0071364 cellular response to epidermal growth factor stimulus
GO:0000049 tRNA binding
GO:0000166 nucleotide binding
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0019901 protein kinase binding
GO:0044822 poly(A) RNA binding
GO:0005615 extracellular space
GO:0005634 nucleus
GO:0005730 nucleolus |
| Organisms for which functions have been demonstrated | Oryctolagus cuniculus (rabbit) |
| Sequence length | 462 amino acids |
| FASTA sequence | >sp|P68105|EF1A1_RABIT Elongation factor 1-alpha 1 OS=Oryctolagus cuniculus GN=EEF1A1 PE=1 SV=1
MGKEKTHINIVVIGHVDSGKSTTTGHLIYKCGGIDKRTIEKFEKEAAEMGKGSFKYAWVLDKLKAERERGITIDISLWKFETSKYYVTIIDAPGHRDFIKNMITGTSQADCAVLIVAAGVGEFEAGISKNGQTREHALLAYTLGVKQLIVGVNKMDSTEPPYSQKRYEEIVKEVSTYIKKIGYNPDTVAFVPISGWNGDNMLEPSANMPWFKGWKVTRKDGNASGTTLLEALDCILPPTRPTDKPLRLPLQDVYKIGGIGTVPVGRVETGVLKPGMVVTFAPVNVTTEVKSVEMHHEALSEALPGDNVGFNVKNVSVKDVRRGNVAGDSKNDPPMEAAGFTAQVIILNHPGQISAGYAPVLDCHTAHIACKFAELKEKIDRRSGKKLEDGPKFLKSGDAAIVDMVPGKPMCVESFSDYPP |
| Structure Information |
| PDB ID | 4C0S_A, 92.19% similarity to Chain A, Elongation Factor 1-alpha 2 [Oryctolagus cuniculus] |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-7, 128-129, 223, 325-333, 383-390, 445-462 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | translation elongation factor |
| References for function | |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | binds and severs microtubules |
| References for function | 7939665 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |