General Information |
MoonProt ID | 322 |
First appeared in release | 2.0 |
Name(s) | EF-1alpha, elongation factor 1 alpha |
UniProt ID | P17506 (EF1A1_XENLA) |
GO terms | GO:0006412 translation
GO:0006414 translational elongation
GO:0000166 nucleotide binding
GO:0003746 translation elongation factor activity
GO:0003924 GTPase activity
GO:0005515 protein binding
GO:0005525 GTP binding
GO:0005737 cytoplasm |
Organisms for which functions have been demonstrated | Xenopus laevis (African clawed frog) |
Sequence length | 463 amino acids |
FASTA sequence | >sp|P17506|EF1A1_XENLA Elongation factor 1-alpha OS=Xenopus laevis PE=1 SV=2
MTDKAPQKTHLNIVIIGHVDSGKSTTTGHLIYKCGGFDPRALEKVEAAAAQLGKSSFKFAWILDKLKAERERGITIDISLWKFQTNRFTITIIDAPGHRDFIKNMITGTSQADVALLVVSAATGEFEAGVSRNGQTREHALLAYTMGVKQLIVCVNKMDLTDPPYSHKRFDEVVRNVMVYLKKIGYNPATIPFVPVSGWTGENISSPSQKMGWFKGWKVKRKDGFTKGQSLLEVLDALVPPVRPANKPLRLPLQDVYKIGGIGTVPVGKIETGILKPGMTISFAPSGFSAEVKSIEMHHEPLQMAFPGFNIGFNVKNIAVKSLKRGNVAGNSKSDPPTEASSFTAQVIILNHPGFIKAGYSPVIDCHTAHITCQFAELQEKIDRRTGKKLEDNPGLLKSGDAAIITLKPIKPFCVERFFDYPPLGRFAARDLKQTVAVGVVKSVEHKAGAAARRQVQKPVLVK |
Structure Information |
PDB ID | |
Quaternary structure | |
SCOP | |
CATH | |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | 1-9, 130-132, 329-337, 446-463 |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | translation elongation factor |
References for function | |
E.C. number | |
Location of functional site(s) | |
Cellular location of function | cytoplasm |
Comments | |
Function 2 |
Function description | binds and severs microtubules |
References for function | Shiina N, Gotoh Y, Kubomura N, Iwamatsu A, Nishida E. Microtubule severing by elongation factor 1 alpha. Science. 1994 266(5183):282-5. PMID: 7939665. |
E.C. number | |
Location of functional site(s) | |
Cellular location of function | cytoplasm |
Comments | |