| General Information |
| MoonProt ID | 331 |
| First appeared in release | 2.0 |
| Name(s) | enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase, Gene: eno |
| UniProt ID | Q27727 (ENO_PLAFA) |
| GO terms | GO:0006096 glycolytic process
GO:0000287 magnesium ion binding
GO:0004634 phosphopyruvate hydratase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0000015 phosphopyruvate hydratase complex
GO:0005737 cytoplasm |
| Organisms for which functions have been demonstrated | Plasmodium falciparum |
| Sequence length | 446 amino acids |
| FASTA sequence | >sp|Q27727|ENO_PLAFA Enolase OS=Plasmodium falciparum GN=ENO PE=3 SV=1
MAHVITRINAREILDSRGNPTVEVDLETNLGIFRAAVPSGASTGIYEALELRDNDKSRYLGKGVQKAIKNINEIIAPKLIGMNCTEQKKIDNLMVEELDGSKNEWGWSKSKLGANAILAISMAVCRAGAAPNKVSLYKYLAQLAGKKSDQMVLPVPCLNVINGGSHAGNKLSFQEFMIVPVGAPSFKEALRYGAEVYHTLKSEIKKKYGIDATNVGDEGGFAPNILNANEALDLLVTAIKSAGYEGKVKIAMDVAASEFYNSENKTYDLDFKTPNNDKSLVKTGAQLVDLYIDLVKKYPIVSIEDPFDQDDWENYAKLTAAIGKDVQIVGDDLLVTNPTRITKALEKNACNALLLKVNQIGSITEAIEACLLSQKNNWGVMVSHRSGETEDVFIADLVVALRTGQIKTGAPCRSERNAKYNQLLRIEESLGNNAVFAGEKFRLQLN |
| Structure Information |
| PDB ID | |
| Quaternary structure | |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-5, 442-446 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase, 2-phospho-D-glycerate -> phosphoenolpyruvate, in glycolysis |
| References for function | PMID: 8125109 |
| E.C. number | 4.2.1.11 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | plasminogen binding, also maybe EBP binding, also maybe adhesin |
| References for function | Ghosh AK, Coppens I, Gårdsvoll H, Ploug M, Jacobs-Lorena M.Plasmodium ookinetes coopt mammalian plasminogen to invade the mosquito midgut. Proc Natl Acad Sci U S A. 2011 Oct 11;108(41):17153-8. doi: 10.1073/pnas.1103657108. PMID: 21949403 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |