| General Information |
| MoonProt ID | 333 |
| First appeared in release | 2.0 |
| Name(s) | enolase, 2-phospho-D-glycerate hydro-lyase, 2-phosphoglycerate dehydratase Gene: eno |
| UniProt ID | F5WVK5 (F5WVK5_STRG1) |
| GO terms | GO:0006096 glycolytic process
GO:0000287 magnesium ion binding
GO:0004634 phosphopyruvate hydratase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0000015 phosphopyruvate hydratase complex
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0009986 cell surface |
| Organisms for which functions have been demonstrated | Streptococcus gallolyticus (Gram positive bacterium) |
| Sequence length | 432 amino acids |
| FASTA sequence | >tr|F5WVK5|F5WVK5_STRG1 Enolase OS=Streptococcus gallolyticus (strain ATCC 43143 / F-1867) GN=eno PE=3 SV=1
MSIITDVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTGEHEAVELRDGDKSRYNGLGTQKAVDNVNNIIAEAIIGFDVRDQQAIDRAMIALDGTPNKGKLGANAILGVSIAVARAAADYLEVPLYSYLGGFNTKVLPTPMMNIINGGSHSDAPIAFQEFMIVPAGAPTFKEALRWGAEIFHTLKKILKERGLETAVGDEGGFAPKFDGTEDAVETIIKAIETAGYKPGEDVFLGFDCASSEFYDNGIYDYTKFEGEGGAKRTASEQIDYIEELVNKYPIITIEDAMDENDWDGWKELTKRLGKRVQLVGDDFFVTNTSYLERGIKEEAANSILIKVNQIGTLTETFEAIEMAKEAGYTAVVSHRSGETEDSTIADIAVATNAGQIKTGSLSRTDRIAKYNQLLRIEDQLGEVAEYRGLKSFYNLKK |
| Structure Information |
| PDB ID | no, but some from homologues |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-4, 41-43, 429-432 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enolase, enzyme, in glycolysis, 2-phosphoglycerate => phosphoenolpyruvate |
| References for function | |
| E.C. number | 4.2.1.11 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | binds Cytokeratin 8 (CK8) of host cells |
| References for function | Boleij, A., Laarakkers, C.M., Gloerich, J., Swinkels, D.W. and Tjalsma, H. (2011) Surface-affinity profiling to identify host-pathogen interactions. Infect. Immun. 79, 4777–4783. PMID: 21947776 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |