| General Information |
| MoonProt ID | 336 |
| First appeared in release | 2.0 |
| Name(s) | eps15, Epidermal growth factor receptor substrate 15, Gene: EPS15 |
| UniProt ID | P42566 (EPS15_HUMAN) |
| GO terms | GO:0006810 transport
GO:0006895 Golgi to endosome transport
GO:0006897 endocytosis
GO:0007173 epidermal growth factor receptor signaling pathway
GO:0008283 cell proliferation
GO:0015031 protein transport
GO:0016050 vesicle organization
GO:0019065 receptor-mediated endocytosis of virus by host cell
GO:0032456 endocytic recycling
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0046718 viral entry into host cell
GO:0048268 clathrin coat assembly
GO:0005509 calcium ion binding
GO:0005515 protein binding |
| Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal) |
| Sequence length | 896 amino acids |
| FASTA sequence | >sp|P42566|EPS15_HUMAN Epidermal growth factor receptor substrate 15 OS=Homo sapiens GN=EPS15 PE=1 SV=2
MAAAAQLSLTQLSSGNPVYEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALRLVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASLQKNIIGSSPVADFSAIKELDTLNNEIVDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKEVRKKCAEEAQLISSLKAELTSQESQISTYEEELAKAREELSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLENHNSQLNWCSSPHSILVNGATDYCSLSTSSSETANLNEHVEGQSNLESEPIHQESPARSSPELLPSGVTDENEVTTAVTEKVCSELDNNRHSKEEDPFNVDSSSLTGPVADTNLDFFQSDPFVGSDPFKDDPFGKIDPFGGDPFKGSDPFASDCFFRQSTDPFATSSTDPFSAANNSSITSVETLKHNDPFAPGGTVVAASDSATDPFASVFGNESFGGGFADFSTLSKVNNEDPFRSATSSSVSNVVITKNVFEETSVKSEDEPPALPPKIGTPTRPCPLPPGKRSINKLDSPDPFKLNDPFQPFPGNDSPKEKDPEIFCDPFTSATTTTNKEADPSNFANFSAYPSEEDMIEWAKRESEREEEQRLARLNQQEQEDLELAIALSKSEISEA |
| Structure Information |
| PDB ID | 1EH2, 1C07, 1F8H, 2JXC, 1FF1 |
| Quaternary structure | |
| SCOP | EF Hand-like |
| CATH | 1.10.238.10 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | 4.42%,301-340 |
| Predicted Disorder Regions | 1-13, 90-120, 140-142, 213-214, 216- 225, 236-239, 295-429, 436-473, 482-485, 500-896 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | binds clathrin, clathrin adapter in post-Golgi trafficking, also role in assembly of clathrin-coated pits |
| References for function | Mettlen M., Stoeber M., Loerke D., Antonescu C.N., Danuser G., Schmid S.L. Endocytic accessory proteins are functionally distinguished by their differential effects on the maturation of clathrin-coated pits. Mol. Biol. Cell 20:3251-3260(2009). PMID: 19458185. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | transcription activation |
| References for function | Vecchi M, Polo S, Poupon V, van de Loo JW, Benmerah A, Di Fiore PP. Nucleocytoplasmic shuttling of endocytic proteins. J Cell Biol. 2001 Jun 25;153(7):1511-7. PMID: 11425879. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | nucleus |
| Comments | |