| General Information |
| MoonProt ID | 337 |
| First appeared in release | 2.0 |
| Name(s) | Fructose-1,6-bisphosphatase, FBP1, FBPase 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase 1, Liver FBPase, Gene: FBP1 |
| UniProt ID | P09467 (F16P1_HUMAN) |
| GO terms | GO:0005975 carbohydrate metabolic process
GO:0006001 fructose catabolic process
GO:0006002 fructose 6-phosphate metabolic process
GO:0006094 gluconeogenesis
GO:0006111 regulation of gluconeogenesis
GO:0008152 metabolic process
GO:0016311 dephosphorylation
GO:0030308 negative regulation of cell growth
GO:0035690 cellular response to drug
GO:0045820 negative regulation of glycolytic process
GO:0046580 negative regulation of Ras protein signal transduction
GO:0051289 protein homotetramerization
GO:0071286 cellular response to magnesium ion
GO:0003824 catalytic activity
GO:0005515 protein binding
GO:0016208 AMP binding
GO:0016787 hydrolase activity
GO:0016791 phosphatase activity
GO:0042132 fructose 1,6-bisphosphate 1-phosphatase activity
GO:0042578 phosphoric ester hydrolase activity
GO:0042802 identical protein binding |
| Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal) |
| Sequence length | 338 amino acids |
| FASTA sequence | >sp|P09467|F16P1_HUMAN Fructose-1,6-bisphosphatase 1 OS=Homo sapiens GN=FBP1 PE=1 SV=5
MADQAPFDTDVNTLTRFVMEEGRKARGTGELTQLLNSLCTAVKAISSAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVMNMLKSSFATCVLVSEEDKHAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSVGTIFGIYRKKSTDEPSEKDALQPGRNLVAAGYALYGSATMLVLAMDCGVNCFMLDPAIGEFILVDKDVKIKKKGKIYSLNEGYARDFDPAVTEYIQRKKFPPDNSAPYGARYVGSMVADVHRTLVYGGIFLYPANKKSPNGKLRLLYECNPMAYVMEKAGGMATTGKEAVLDVIPTDIHQRAPVILGSPDDVLEFLKVYEKHSAQ |
| Structure Information |
| PDB ID | 4MJO, 2FIE, 2FHY, 3A29, 1FTA |
| Quaternary structure | |
| SCOP | Carbohydrate phosphatase |
| CATH | 3.30.540.10, 3.40.190.80 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-10, 333-338 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | fructose-1,6-bisphosphatase 1, enzyme in gluconeogenesis, D-fructose 1,6-bisphosphate + H2O => D-fructose 6-phosphate + phosphate |
| References for function | |
| E.C. number | 3.1.3.11 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | binds to HIF (hypoxia inducible factor) protein and inhibits nuclear HIF action |
| References for function | 25043030 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | nucleus |
| Comments | catalytic function not needed for this function |