| General Information |
| MoonProt ID | 340 |
| First appeared in release | 2.0 |
| Name(s) | GAPDH, glyceraldehyde-3-phosphate dehydrogenase, Gene: GAPDH |
| UniProt ID | D9IL10 (D9IL10_HAECO) |
| GO terms | GO:0006006 glucose metabolic process
GO:0006096 glycolytic process
GO:0055114 oxidation-reduction process
GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0050661 NADP binding
GO:0051287 NAD binding |
| Organisms for which functions have been demonstrated | Haemonchus contortus (Barber pole worm) |
| Sequence length | 341 amino acids |
| FASTA sequence | >tr|D9IL10|D9IL10_HAECO Glyceraldehyde-3-phosphate dehydrogenase OS=Haemonchus contortus GN=GAPDH PE=2 SV=1
MVKPKVGINGCGRIGRLVLRAAVEKEPAEVVAVNDPFINIDYMVYLFKYDSTHGRFKGTVAHEGEHLVVSKEGKSTHRIKVHNSKDPAEIKWGADGAEYIVESTGVFTTVEKASAHLKGGAKKVVISAPSADAPMFVMGVNHETYNAANNHIISNASCTTNCLAPLAKVINDNFGIIEGLMTTVHATTATQKTVDGPSGKLWRDGRGAAQNIIPASTGAAKAVGKVIPTLNGKLTGMAFRVPTPDVSVVDLTCRLEKPASMDDIKKVIKSAADGPMKGILGYTEDQVVSTDFVSDTHSSIFDAGACISLNPNFVKLISWYDNEYGYSHRVVDLLAYIASKA |
| Structure Information |
| PDB ID | None, but some are available from homologues |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-3, 338-341 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | GAPDH, glyceraldehyde-3-phosphate dehydrogenase, in glycolysis, D-glyceraldehyde 3-phosphate + phosphate + NAD+ -> 3-phospho-D-glyceroyl phosphate + NADH |
| References for function | 23927077 |
| E.C. number | 1.2.1.12 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | binding alternative complement pathway protein C3, inhibit complement cascade, evade host immunity |
| References for function | 23927077 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | nematode species infects sheep and goats gastrointestinal tract |