Protein Information

General Information
MoonProt ID344
First appeared in release2.0
Name(s)GAPDH, glyceraldehyde-3-phosphate dehydrogenase, Gene: Gapdh
UniProt IDP16858 (G3P_MOUSE)
GO termsGO:0000226 microtubule cytoskeleton organization GO:0006006 glucose metabolic process GO:0006096 glycolytic process GO:0006417 regulation of translation GO:0006915 apoptotic process GO:0007275 multicellular organism development GO:0017148 negative regulation of translation GO:0035606 peptidyl-cysteine S-trans-nitrosylation GO:0050821 protein stabilization GO:0051402 neuron apoptotic process GO:0055114 oxidation-reduction process GO:0071346 cellular response to interferon-gamma GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity GO:0005515 protein binding GO:0008017 microtubule binding GO:0016491 oxidoreductase activity GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor GO:0016740 transferase activity GO:0019899 enzyme binding GO:0035605 peptidyl-cysteine S-nitrosylase activity GO:0042802 identical protein binding GO:0050661 NADP binding GO:0051287 NAD binding GO:0005634 nucleus GO:0005737 cytoplasm GO:0005739 mitochondrion GO:0005811 lipid particle GO:0005829 cytosol GO:0005856 cytoskeleton GO:0005886 plasma membrane GO:0015630 microtubule cytoskeleton GO:0016020 membrane GO:0030529 intracellular ribonucleoprotein complex GO:0031965 nuclear membrane GO:0031982 vesicle GO:0043209 myelin sheath GO:0043231 intracellular membrane-bounded organelle GO:0070062 extracellular exosome GO:0097452 GAIT complex
Organisms for which functions have been demonstratedMus musculus (mouse)
Sequence length333 amino acids
Structure Information
PDB IDnone for mouse, but homologues for other species available
Quaternary structuretetramer in glycolysis
Function 1
Function descriptionglyceraldehyde 3-phosphate dehydrogenase, in glycolysis, D-glyceraldehyde 3-phosphate (G3P) <-> 3-phospho-D-glyceroyl phosphate
References for function
E.C. number1.2.1.12
Location of functional site(s)
Cellular location of functioncytoplasm
Function 2
Function descriptionbind mRNA AU-rich element (ARE), regulation of cyclo-oxygenase-2 (COX-2) expressio, binding to COX-2 mRNA
References for function23000033
E.C. number
Location of functional site(s)
Cellular location of function