| General Information |
| MoonProt ID | 344 |
| First appeared in release | 2.0 |
| Name(s) | GAPDH, glyceraldehyde-3-phosphate dehydrogenase, Gene: Gapdh |
| UniProt ID | P16858 (G3P_MOUSE) |
| GO terms | GO:0000226 microtubule cytoskeleton organization
GO:0006006 glucose metabolic process
GO:0006096 glycolytic process
GO:0006417 regulation of translation
GO:0006915 apoptotic process
GO:0007275 multicellular organism development
GO:0017148 negative regulation of translation
GO:0035606 peptidyl-cysteine S-trans-nitrosylation
GO:0050821 protein stabilization
GO:0051402 neuron apoptotic process
GO:0055114 oxidation-reduction process
GO:0071346 cellular response to interferon-gamma
GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0016740 transferase activity
GO:0019899 enzyme binding
GO:0035605 peptidyl-cysteine S-nitrosylase activity
GO:0042802 identical protein binding
GO:0050661 NADP binding
GO:0051287 NAD binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005811 lipid particle
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0015630 microtubule cytoskeleton
GO:0016020 membrane
GO:0030529 intracellular ribonucleoprotein complex
GO:0031965 nuclear membrane
GO:0031982 vesicle
GO:0043209 myelin sheath
GO:0043231 intracellular membrane-bounded organelle
GO:0070062 extracellular exosome
GO:0097452 GAIT complex |
| Organisms for which functions have been demonstrated | Mus musculus (Mouse, mammal) |
| Sequence length | 333 amino acids |
| FASTA sequence | >sp|P16858|G3P_MOUSE Glyceraldehyde-3-phosphate dehydrogenase OS=Mus musculus GN=Gapdh PE=1 SV=2
MVKVGVNGFGRIGRLVTRAAICSGKVEIVAINDPFIDLNYMVYMFQYDSTHGKFNGTVKAENGKLVINGKPITIFQERDPTNIKWGEAGAEYVVESTGVFTTMEKAGAHLKGGAKRVIISAPSADAPMFVMGVNHEKYDNSLKIVSNASCTTNCLAPLAKVIHDNFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGAAQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTPNVSVVDLTCRLEKPAKYDDIKKVVKQASEGPLKGILGYTEDQVVSCDFNSNSHSSTFDAGAGIALNDNFVKLISWYDNEYGYSNRVVDLMAYMASKE |
| Structure Information |
| PDB ID | none for mouse, but homologues for other species available |
| Quaternary structure | tetramer in glycolysis |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1, 330-333 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | glyceraldehyde 3-phosphate dehydrogenase, in glycolysis, D-glyceraldehyde 3-phosphate (G3P) <-> 3-phospho-D-glyceroyl phosphate |
| References for function | |
| E.C. number | 1.2.1.12 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | bind mRNA AU-rich element (ARE), regulation of cyclo-oxygenase-2 (COX-2) expressio, binding to COX-2 mRNA |
| References for function | 23000033 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |