| General Information |
| MoonProt ID | 345 |
| First appeared in release | 2.0 |
| Name(s) | Glyceraldehyde-3-phosphate dehydrogenase, GAPDH Gene: GAPDH |
| UniProt ID | P46406 (G3P_RABIT) |
| GO terms | GO:0000226 microtubule cytoskeleton organization
GO:0006006 glucose metabolic process
GO:0006096 glycolytic process
GO:0006417 regulation of translation
GO:0006915 apoptotic process
GO:0035606 peptidyl-cysteine S-trans-nitrosylation
GO:0050821 protein stabilization
GO:0051402 neuron apoptotic process
GO:0055114 oxidation-reduction process
GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0016740 transferase activity
GO:0035605 peptidyl-cysteine S-nitrosylase activity
GO:0050661 NADP binding
GO:0051287 NAD binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0015630 microtubule cytoskeleton
GO:0097452 GAIT complex |
| Organisms for which functions have been demonstrated | Oryctolagus cuniculus (rabbit , a mammal) Also human and S. suis |
| Sequence length | 333 amino acids |
| FASTA sequence | >sp|P46406|G3P_RABIT Glyceraldehyde-3-phosphate dehydrogenase OS=Oryctolagus cuniculus GN=GAPDH PE=1 SV=3
MVKVGVNGFGRIGRLVTRAAFNSGKVDVVAINDPFIDLHYMVYMFQYDSTHGKFHGTVKAENGKLVINGKAITIFQERDPANIKWGDAGAEYVVESTGVFTTMEKAGAHLKGGAKRVIISAPSADAPMFVMGVNHEKYDNSLKIVSNASCTTNCLAPLAKVIHDHFGIVEGLMTTVHAITATQKTVDGPSGKLWRDGRGAAQNIIPASTGAAKAVGKVIPELNGKLTGMAFRVPTPNVSVVDLTCRLEKAAKYDDIKKVVKQASEGPLKGILGYTEDQVVSCDFNSATHSSTFDAGAGIALNDHFVKLISWYDNEFGYSNRVVDLMVHMASKE |
| Structure Information |
| PDB ID | 1J0X |
| Quaternary structure | tetramer |
| SCOP | NA |
| CATH | 3.40.50.720 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1, 330-333 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | Glyceraldehyde-3-phosphate dehydrogenase, GAPDH, in glycolysis, conversion of glyceraldehyde 3-phosphate into glycerate 1,3-bisphosphate |
| References for function | |
| E.C. number | 1.2.1.12 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | heme binding protein, required for the insertion of cellular heme
into inducible nitric oxide synthase |
| References for function | 20921417, 22957700 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |