| General Information |
| MoonProt ID | 348 |
| First appeared in release | 2.0 |
| Name(s) | GAPDH, Tdh3, Glyceraldehyde-3-phosphate dehydrogenase 3, GPD3
Gene: TDH3 |
| UniProt ID | P00359 (G3P3_YEAST) |
| GO terms | GO:0006006 glucose metabolic process
GO:0006094 gluconeogenesis
GO:0006096 glycolytic process
GO:0006915 apoptotic process
GO:0055114 oxidation-reduction process
GO:0072593 reactive oxygen species metabolic process
GO:0003723 RNA binding
GO:0004365 glyceraldehyde-3-phosphate dehydrogenase (NAD+) (phosphorylating) activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0050661 NADP binding
GO:0051287 NAD binding
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005811 lipid particle
GO:0009277 fungal-type cell wall |
| Organisms for which functions have been demonstrated | Saccharomyces cerevisiae (yeast, fungi) |
| Sequence length | 332 amino acids |
| FASTA sequence | >sp|P00359|G3P3_YEAST Glyceraldehyde-3-phosphate dehydrogenase 3 OS=Saccharomyces cerevisiae (strain ATCC 204508 / S288c) GN=TDH3 PE=1 SV=3
MVRVAINGFGRIGRLVMRIALSRPNVEVVALNDPFITNDYAAYMFKYDSTHGRYAGEVSHDDKHIIVDGKKIATYQERDPANLPWGSSNVDIAIDSTGVFKELDTAQKHIDAGAKKVVITAPSSTAPMFVMGVNEEKYTSDLKIVSNASCTTNCLAPLAKVINDAFGIEEGLMTTVHSLTATQKTVDGPSHKDWRGGRTASGNIIPSSTGAAKAVGKVLPELQGKLTGMAFRVPTVDVSVVDLTVKLNKETTYDEIKKVVKAAAEGKLKGVLGYTEDAVVSSDFLGDSHSSIFDASAGIQLSPKFVKLVSWYDNEYGYSTRVVDLVEHVAKA |
| Structure Information |
| PDB ID | 3PYM, 4IQ8 |
| Quaternary structure | |
| SCOP | NA |
| CATH | 3.40.50.720 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1, 330-332 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | GAPDH, glyceraldehyde 3-phosphate dehydrogenase |
| References for function | Ringel AE, Ryznar R, Picariello H, Huang, KL, Lazarus, AG, Holmes SG. (2013) Yeast Tdh3 (glyceraldehyde 3-phosphate dehydrogenase) is a Sir2-interacting factor that regulates transcriptional silencing and rDNA recombination. PLoS Genet. 9, e1003871 |
| E.C. number | 1.2.1.12 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | binds to Sir2, regulates gene silencing by influencing Sir2’s association with chromatin, especially near telomeres |
| References for function | Ringel AE, Ryznar R, Picariello H, Huang, KL, Lazarus, AG, Holmes SG. (2013) Yeast Tdh3 (glyceraldehyde 3-phosphate dehydrogenase) is a Sir2-interacting factor that regulates transcriptional silencing and rDNA recombination. PLoS Genet. 9, e1003871 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | nucleus |
| Comments | showed mutant proteins deficient in catalytic activity can still function in other function |