General Information |
MoonProt ID | 356 |
First appeared in release | 2.0 |
Name(s) | Hal3, thymidylate synthase, phosphopantothenoylcysteine decarboxylase, PPCDC, Gene: SPAC15E1.04 |
UniProt ID | Q9UTI7 (TYSY_SCHPO) |
GO terms | GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation
GO:0003824 catalytic activity
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0016740 transferase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0005737 cytoplasm
GO:0005829 cytosol |
Organisms for which functions have been demonstrated | Schizosaccharomyces pombe |
Sequence length | 625 amino acids |
FASTA sequence | >sp|Q9UTI7|TYSY_SCHPO Probable thymidylate synthase OS=Schizosaccharomyces pombe (strain 972 / ATCC 24843) GN=SPAC15E1.04 PE=3 SV=1
MSQPLHARFATRAVKNPMILEKERQLTDSKYHILVAATGSVAAIKLTLIVKSLLTYKGVDVQVVLTDPARNFVEKEDLTALGVNVYNNADDWKNWDGLECPITHIELRRWAHLLLIAPLSANTMAKMANGLCDNLLTSLIRAWAPLKPILLAPAMNTLMWTNPITQEHLSAISRIYKNSEFIMPIEKVLACGDIGMGGMAEWRNIVGRVADKLQLEQKSVLPNAVKNIDGQDDDSSEQTAAFEEYDDDDDDDVDDNEQSNSMIETSANADITPKASLLPSTTESSISKDHETSQAPLGSESVDTQASENVTTKPEPPVPFTSSEYRNTEEEQYLNLIRYILENGQSRPDRTGTGTRSVFAPPQLRFSLRNNTLPLLTTKRVFLRGVLEELLWFIHGDTNANHLSEKGIHIWDGNGSREFLDSRGLTDRKVGDLGPIYGFQWRHFGAQYVDCDTDYTNKGVDQLAQVISTLKLNPYDRRIILSAWNPLAIPEMALPPCHIFCQFYVSEPCKPGGKPQLSSMMYQRSADMGLGVPFNIASYSLLTHMIAHMCGYEAAEFVHVMGDCHIYNDHLEALQTQLERVPKAFPKLFFKRDAKDIGSIDSFSVDDFAVEGYNPYGPIKMKMSV |
Structure Information |
PDB ID | None, some structures of homologues of TS domain available |
Quaternary structure | hetero and homo trimers |
SCOP | NA |
CATH | NA |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | 1-15, 25-47, 473-474 |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | phosphopantothenoylcysteine decarboxylase, decarboxylation of phosphopahtothenoyl-L-cysteine, in CoA biosynthesis, PPCDC |
References for function | 23962284 |
E.C. number | 4.1.1.36 |
Location of functional site(s) | |
Cellular location of function | |
Comments | |
Function 2 |
Function description | inhibitor of serine/threoinine phosphatase Pzh1 |
References for function | 23962284 |
E.C. number | |
Location of functional site(s) | |
Cellular location of function | |
Comments | |