| General Information |
| MoonProt ID | 359 |
| First appeared in release | 2.0 |
| Name(s) | hexokinase 1, Gene: HXK1 |
| UniProt ID | Q42525 (HXK1_ARATH) |
| GO terms | GO:0001678 cellular glucose homeostasis
GO:0005975 carbohydrate metabolic process
GO:0006096 glycolytic process
GO:0010148 transpiration
GO:0010182 sugar mediated signaling pathway
GO:0010255 glucose mediated signaling pathway
GO:0012501 programmed cell death
GO:0016310 phosphorylation
GO:0019320 hexose catabolic process
GO:0046835 carbohydrate phosphorylation
GO:0051156 glucose 6-phosphate metabolic process
GO:0090332 stomatal closure
GO:0009750 response to fructose
GO:0000166 nucleotide binding
GO:0004340 glucokinase activity
GO:0004396 hexokinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0005536 glucose binding
GO:0008270 zinc ion binding
GO:0008865 fructokinase activity
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0019158 mannokinase activity
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005741 mitochondrial outer membrane
GO:0005773 vacuole
GO:0005774 vacuolar membrane
GO:0005829 cytosol
GO:0009536 plastid
GO:0016020 membrane
GO:0016021 integral component of membrane |
| Organisms for which functions have been demonstrated | Arabidopsis thaliana (Mouse-ear cress, a plant) |
| Sequence length | 496 amino acids |
| FASTA sequence | >sp|Q42525|HXK1_ARATH Hexokinase-1 OS=Arabidopsis thaliana GN=HXK1 PE=1 SV=2
MGKVAVGATVVCTAAVCAVAVLVVRRRMQSSGKWGRVLAILKAFEEDCATPISKLRQVADAMTVEMHAGLASDGGSKLKMLISYVDNLPSGDEKGLFYALDLGGTNFRVMRVLLGGKQERVVKQEFEEVSIPPHLMTGGSDELFNFIAEALAKFVATECEDFHLPEGRQRELGFTFSFPVKQTSLSSGSLIKWTKGFSIEEAVGQDVVGALNKALERVGLDMRIAALVNDTVGTLAGGRYYNPDVVAAVILGTGTNAAYVERATAIPKWHGLLPKSGEMVINMEWGNFRSSHLPLTEFDHTLDFESLNPGEQILEKIISGMYLGEILRRVLLKMAEDAAFFGDTVPSKLRIPFIIRTPHMSAMHNDTSPDLKIVGSKIKDILEVPTTSLKMRKVVISLCNIIATRGARLSAAGIYGILKKLGRDTTKDEEVQKSVIAMDGGLFEHYTQFSECMESSLKELLGDEASGSVEVTHSNDGSGIGAALLAASHSLYLEDS |
| Structure Information |
| PDB ID | 4QS7, 4QS9 |
| Quaternary structure | |
| SCOP | NA |
| CATH | 3.40.367.20, 3.30.420.40 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-8, 71-74, 162-168, 491-496 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | hexokinase, ATP + D-hexose => ADP + D-hexose 6-phosphate |
| References for function | |
| E.C. number | 2.7.1.1 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | binds to vacuolar H+-ATPase B1 (VHA-B1) and the 19S regulatory particle of proteasome subunit (RPT5B) to modulate transcription of specific target genes |
| References for function | Cho YH, Yoo SD, Sheen J. Regulatory functions of nuclear hexokinase1 complex in glucose signaling. Cell. 2006 Nov 3;127(3):579-89. PMID: 17081979 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | nucleus |
| Comments | catalytic activity not needed for this function |