| General Information |
| MoonProt ID | 36 |
| First appeared in release | 1.0 |
| Name(s) | Enolase
2-phospho-D-glycerate hydro-lyase
2-phosphoglycerate dehydratase
Gene Name: eno
|
| UniProt ID | Q97QS2 |
| GO terms | GO:0006096 glycolysis
GO:0000287 magnesium ion binding
GO:0004634 phosphopyruvate hydratase activity
GO:0016829 lyase activity
GO:0046872 metal ion binding
GO:0000015 phosphopyruvate hydratase complex
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0009986 cell surface |
| Organisms for which functions have been demonstrated | Streptococcus pneumoniae (Gram positive bacterium) |
| Sequence length | 434 |
| FASTA sequence | >sp|Q97QS2|ENO_STRPN Enolase OS=Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4) GN=eno PE=1 SV=1
MSIITDVYAREVLDSRGNPTLEVEVYTESGAFGRGMVPSGASTGEHEAVELRDGDKSRYGGLGTQKAVDNVNNIIAEAIIGYDVRDQQAIDRAMIALDGTPNKGKLGANAILGVSIAVARAAADYLEIPLYSYLGGFNTKVLPTPMMNIINGGSHSDAPIAFQEFMILPVGAPTFKEALRYGAEIFHALKKILKSRGLETAVGDEGGFAPRFEGTEDGVETILAAIEAAGYVPGKDVFIGFDCASSEFYDKERKVYDYTKFEGEGAAVRTSAEQIDYLEELVNKYPIITIEDGMDENDWDGWKALTERLGKKVQLVGDDFFVTNTDYLARGIQEGAANSILIKVNQIGTLTETFEAIEMAKEAGYTAVVSHRSGETEDSTIADIAVATNAGQIKTGSLSRTDRIAKYNQLLRIEDQLGEVAEYRGLKSFYNLKK
|
| Structure Information |
| PDB ID | 1W6T |
| Quaternary structure | |
| SCOP | Enolase N-terminal domain-like, TIM beta/alpha-barrel |
| CATH | 3.30.390.10, 3.20.20.120 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-3,264-266,432-434 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enolase, enzyme
2-phospho-D-glycerate => phosphoenolpyruvate + H2O
Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate
Carbohydrate degradation, glycolysis |
| References for function | Antikainen J, Kuparinen V, L?hteenm?ki K, Korhonen TK. Enolases from Gram-positive bacterial pathogens and commensal lactobacilli share functional similarity in virulence-associated traits. FEMS Immunol Med Microbiol. 2007 Dec;;51(3):526-34.Epub 2007 Sep 24. PMID: 17892475. |
| E.C. number | 4.2.1.11 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | binds plasminogen |
| References for function | Antikainen J, Kuparinen V, L?hteenm?ki K, Korhonen TK. Enolases from Gram-positive bacterial pathogens and commensal lactobacilli share functional similarity in virulence-associated traits. FEMS Immunol Med Microbiol. 2007 Dec;51(3):526-34.Epub 2007 Sep 24.
PMID: 17892475.
Kolberg J, Aase A, Bergmann S, Herstad TK, R?dal G, Frank R, Rohde M, Hammerschmidt S. Streptococcus pneumoniae enolase is important for plasminogen binding despite low abundance of enolase protein on the bacterial cell surface. Microbiology. 2006 May;152(Pt 5):1307-17. PMID:
16622048. |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cell surface |
| Comments | |