| General Information |
| MoonProt ID | 360 |
| First appeared in release | 2.0 |
| Name(s) | Hgt1p, high-affinity glucose transporter 1, CaHgt1p Gene:HGT1 |
| UniProt ID | O74713 (HGT1_CANAX) |
| GO terms | GO:0006810 transport
GO:0008643 carbohydrate transport
GO:0055085 transmembrane transport
GO:0005215 transporter activity
GO:0022857 transmembrane transporter activity
GO:0022891 substrate-specific transmembrane transporter activity
GO:0016020 membrane
GO:0016021 integral component of membrane |
| Organisms for which functions have been demonstrated | Candida albicans (yeast, a fungi, can cause candiadiasis) |
| Sequence length | 545 amino acids |
| FASTA sequence | >sp|O74713|HGT1_CANAX High-affinity glucose transporter OS=Candida albicans GN=HGT1 PE=3 SV=1
MSSKIERIFSGPALKINTYLDKLPKIYNVFFIASISTIAGMMFGFDISSMSAFIGAEHYMRYFNSPGSDIQGFITSSMALGSFFGSIASSFVSEPFGRRLSLLTCAFFWMVGAAIQSSVQNRAQLIIGRIISGIGVGFGSAVAPVYGAELAPRKIRGLIGGMFQFFVTLGIMIMFYLSFGLGHINGVASFRIAWGLQIVPGLCLFLGCFFIPESPRWLAKQGQWEAAEEIVAKIQAHGDRENPDVLIEISEIKDQLLLEESSKQIGYATLFTKKYIQRTFTAIFAQIWQQLTGMNVMMYYIVYIFQMAGYSGNSNLVASSIQYVINTCVTVPALYFIDKVGRRPLLIGGATMMMAFQFGLAGILGQYSIPWPDSGNDSVNIRIPEDNKSASKGAIACCYLFVASFAFTWGVGIWVYCAEIWGDNRVAQRGNAISTSANWILNFAIAMYTPTGFKNISWKTYIIYGVFCFAMATHVYFGFPETKGKRLEEIGQMWEERVPAWRSRSWQPTVPIASDAELARKMEVEHEEDKLMNEDSNSESRENQA |
| Structure Information |
| PDB ID | |
| Quaternary structure | |
| SCOP | |
| CATH | |
| TM Helix Prediction | 12(26-45, 70-92,99-116,126-148,155-177,192-211,283-305,315-337,344-366,395-417,430-452,462-479) |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-8, 71-74, 162-168, 491-496 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | sugar transporter, glucose transporter |
| References for function | 10612724 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | transmembrane protein, cell membrane |
| Comments | |
| Function 2 |
| Function description | complement inhibitor, binds complement regulator FH, binds complement regulator C4BP, protects cells from host complement cascade, complement evasion resulting in reduced formation of the potentially lytic terminal complex (TCC) |
| References for function | Lesiak-Markowicz I, Vogl G, Schwarzmuller T, Speth C, Lass-Florl C, Dierich MP, Kuchler K, Wurzner R. 2011. Candida albicans Hgt1p, a multifunctional evasion molecule: complement inhibitor, CR3 analogue, and
human immunodeficiency virus-binding molecule. J Infect Dis 204:802-809. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | transmembrane protein, cell membrane |
| Comments | |