| General Information |
| MoonProt ID | 374 |
| First appeared in release | 2.0 |
| Name(s) | phosphofructokinase 1, PFK1, |
| UniProt ID | P08237 |
| GO terms | GO:0005980 glycogen catabolic process
GO:0006002 fructose 6-phosphate metabolic process
GO:0006096 glycolytic process
GO:0008152 metabolic process
GO:0016310 phosphorylation
GO:0032024 positive regulation of insulin secretion
GO:0042593 glucose homeostasis
GO:0046716 muscle cell cellular homeostasis
GO:0046835 carbohydrate phosphorylation
GO:0051259 protein oligomerization
GO:0061615 glycolytic process through fructose-6-phosphate
GO:0061621 canonical glycolysis
GO:0093001 glycolysis from storage polysaccharide through glucose-1-phosphate
GO:0000166 nucleotide binding
GO:0003824 catalytic activity
GO:0003872 6-phosphofructokinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0008022 protein C-terminus binding
GO:0008443 phosphofructokinase activity
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0019900 kinase binding
GO:0042802 identical protein binding
GO:0042803 protein homodimerization activity
GO:0046872 metal ion binding
GO:0070061 fructose binding
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005945 6-phosphofructokinase complex
GO:0016324 apical plasma membrane
GO:0070062 extracellular exosome
GO:0097228 sperm principal piece |
| Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal) |
| Sequence length | 780 amino acids |
| FASTA sequence | >sp|P08237|PFKAM_HUMAN ATP-dependent 6-phosphofructokinase, muscle type OS=Homo sapiens GN=PFKM PE=1 SV=2
MTHEEHHAAKTLGIGKAIAVLTSGGDAQGMNAAVRAVVRVGIFTGARVFFVHEGYQGLVDGGDHIKEATWESVSMMLQLGGTVIGSARCKDFREREGRLRAAYNLVKRGITNLCVIGGDGSLTGADTFRSEWSDLLSDLQKAGKITDEEATKSSYLNIVGLVGSIDNDFCGTDMTIGTDSALHRIMEIVDAITTTAQSHQRTFVLEVMGRHCGYLALVTSLSCGADWVFIPECPPDDDWEEHLCRRLSETRTRGSRLNIIIVAEGAIDKNGKPITSEDIKNLVVKRLGYDTRVTVLGHVQRGGTPSAFDRILGSRMGVEAVMALLEGTPDTPACVVSLSGNQAVRLPLMECVQVTKDVTKAMDEKKFDEALKLRGRSFMNNWEVYKLLAHVRPPVSKSGSHTVAVMNVGAPAAGMNAAVRSTVRIGLIQGNRVLVVHDGFEGLAKGQIEEAGWSYVGGWTGQGGSKLGTKRTLPKKSFEQISANITKFNIQGLVIIGGFEAYTGGLELMEGRKQFDELCIPFVVIPATVSNNVPGSDFSVGADTALNTICTTCDRIKQSAAGTKRRVFIIETMGGYCGYLATMAGLAAGADAAYIFEEPFTIRDLQANVEHLVQKMKTTVKRGLVLRNEKCNENYTTDFIFNLYSEEGKGIFDSRKNVLGHMQQGGSPTPFDRNFATKMGAKAMNWMSGKIKESYRNGRIFANTPDSGCVLGMRKRALVFQPVAELKDQTDFEHRIPKEQWWLKLRPILKILAKYEIDLDTSDHAHLEHITRKRSGEAAV
|
| Structure Information |
| PDB ID | 4OMT |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-14, 393-399, 760-780 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | phosphofructokinase, enzyme in glycolysis, first committed step of
glycolysis, by phosphorylating F6P into fructose-1,6-bisphosphate
(F1,6P), ATP + D-fructose 6-phosphate => ADP + D-fructose 1,6-bisphosphate |
| References for function | |
| E.C. number | 2.7.1.11 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | binds TEADs proteins and promotes their interaction with YAP/TAX transcription factors |
| References for function | Enzo E, Santinon G, Pocaterra A, Aragona M, Bresolin S, Forcato M, Grifoni D, Pession A, Zanconato F, Guzzo G, Bicciato S, Dupont S. Aerobic glycolysis tunes YAP/TAZ transcriptional activity. EMBO J. 2015 May 12;34(10):1349-70. doi: 10.15252/embj.201490379. PMID: 25796446 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | nucleus |
| Comments | |