| General Information |
| MoonProt ID | 375 |
| First appeared in release | 2.0 |
| Name(s) | phosphoglycerate kinase 1, PGK, Cell migration-inducing gene 10 protein
Primer recognition protein 2, PRP 2, Gene: PGK1 |
| UniProt ID | P00558 (PGK1_HUMAN) |
| GO terms | GO:0006094 gluconeogenesis
GO:0006096 glycolytic process
GO:0016310 phosphorylation
GO:0030855 epithelial cell differentiation
GO:0061621 canonical glycolysis
GO:0000166 nucleotide binding
GO:0004618 phosphoglycerate kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0016020 membrane
GO:0045121 membrane raft
GO:0070062 extracellular exosome |
| Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal) |
| Sequence length | 417 amino acids |
| FASTA sequence | >sp|P00558|PGK1_HUMAN Phosphoglycerate kinase 1 OS=Homo sapiens GN=PGK1 PE=1 SV=3
MSLSNKLTLDKLDVKGKRVVMRVDFNVPMKNNQITNNQRIKAAVPSIKFCLDNGAKSVVLMSHLGRPDGVPMPDKYSLEPVAVELKSLLGKDVLFLKDCVGPEVEKACANPAAGSVILLENLRFHVEEEGKGKDASGNKVKAEPAKIEAFRASLSKLGDVYVNDAFGTAHRAHSSMVGVNLPQKAGGFLMKKELNYFAKALESPERPFLAILGGAKVADKIQLINNMLDKVNEMIIGGGMAFTFLKVLNNMEIGTSLFDEEGAKIVKDLMSKAEKNGVKITLPVDFVTADKFDENAKTGQATVASGIPAGWMGLDCGPESSKKYAEAVTRAKQIVWNGPVGVFEWEAFARGTKALMDEVVKATSRGCITIIGGGDTATCCAKWNTEDKVSHVSTGGGASLELLEGKVLPGVDALSNI |
| Structure Information |
| PDB ID | 2ZGV, 2XE6 |
| Quaternary structure | |
| SCOP | NA |
| CATH | 3.40.50.1260 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-7, 131-143, 415-417 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | phosphoglycerate kinase, enzyme, reversible conversion of 1,3-diphosphoglycerate to 3-phosphoglycerate |
| References for function | |
| E.C. number | 2.7.2.3 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | binds mRNA, regulates expression of urokinase receptor, "Overexpression in H157 lung squamous carcinoma cells reduced cell surface uPAR expression as well as uPAR-mediated cellular functions at the post-transcriptional level." |
| References for function | 14764427 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | Increased expression of urokinase (uPA) or its receptor (uPAR)
has been inversely correlated with prognosis in lung cancer |