| General Information |
| MoonProt ID | 379 |
| First appeared in release | 2.0 |
| Name(s) | pyruvate kinase 3 (PK3) isoform 2, Pyruvate kinase PKM, Cytosolic thyroid hormone-binding protein, CTHBP, Opa-interacting protein 3, OIP-3, Pyruvate kinase 2/3, Pyruvate kinase muscle isozyme, Thyroid hormone-binding protein 1,THBP1, Tumor M2-PK, p58
Gene: PKM |
| UniProt ID | P14618 (KPYM_HUMAN) |
| GO terms | GO:0001666 response to hypoxia
GO:0001889 liver development
GO:0006006 glucose metabolic process
GO:0006096 glycolytic process
GO:0006754 ATP biosynthetic process
GO:0007584 response to nutrient
GO:0008152 metabolic process
GO:0009629 response to gravity
GO:0010033 response to organic substance
GO:0012501 programmed cell death
GO:0014870 response to muscle inactivity
GO:0016310 phosphorylation
GO:0031100 organ regeneration
GO:0032868 response to insulin
GO:0042866 pyruvate biosynthetic process
GO:0043403 skeletal muscle tissue regeneration
GO:0061621 canonical glycolysis
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004743 pyruvate kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0023026 MHC class II protein complex binding
GO:0030955 potassium ion binding
GO:0043531 ADP binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005929 cilium
GO:0031012 extracellular matrix
GO:0031982 vesicle
GO:0043209 myelin sheath
GO:0070062 extracellular exosome
GO:1903561 extracellular vesicle |
| Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal) |
| Sequence length | 531 amino acids |
| FASTA sequence | >sp|P14618|KPYM_HUMAN Pyruvate kinase PKM OS=Homo sapiens GN=PKM PE=1 SV=4
MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP |
| Structure Information |
| PDB ID | 3GQY, 3SRD, 3U2Z, 4JPG, 1ZJH, 4G1N |
| Quaternary structure | |
| SCOP | NA |
| CATH | 3.40.1380.20, 3.20.20.60, 2.40.33.10 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-14, 399-406 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | pyruvate kinase, ATP + pyruvate -> ADP + phosphoenolpyruvate, in glycolysis |
| References for function | |
| E.C. number | 2.7.1.40 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | interactions with zona pellucida proteins of egg |
| References for function | Petit FM, Serres C, Bourgeon F, Pineau C, Auer J. (2013) Identification of sperm head proteins involved in zona pellucida binding. Hum. Reprod. 28, 852–865. PMID: 23355646. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | sperm membrane |
| Comments | |