| General Information |
| MoonProt ID | 380 |
| First appeared in release | 2.0 |
| Name(s) | pyruvate decarboxylase, KIPdc1, Gene: KIPDC1 |
| UniProt ID | Q12629 (PDC1_KLULA) |
| GO terms | GO:0008152 metabolic process
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004737 pyruvate decarboxylase activity
GO:0016829 lyase activity
GO:0016831 carboxy-lyase activity
GO:0030976 thiamine pyrophosphate binding
GO:0046872 metal ion binding |
| Organisms for which functions have been demonstrated | Kluyveromyces lactis |
| Sequence length | 563 amino acids |
| FASTA sequence | >sp|Q12629|PDC1_KLULA Pyruvate decarboxylase OS=Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) GN=PDC1 PE=1 SV=2
MSEITLGRYLFERLKQVEVQTIFGLPGDFNLSLLDNIYEVPGMRWAGNANELNAAYAADGYARLKGMSCIITTFGVGELSALNGIAGSYAEHVGVLHVVGVPSVSSQAKQLLLHHTLGNGDFTVFHRMSSNISETTAMITDINTAPAEIDRCIRTTYVSQRPVYLGLPANLVDLTVPASLLDTPIDLSLKPNDPEAEEEVIENVLQLIKEAKNPVILADACCSRHDAKAETKKLIDLTQFPAFVTPMGKGSIDEKHPRFGGVYVGTLSSPAVKEAVESADLVLSVGALLSDFNTGSFSYSYKTKNIVEFHSDYTKIRSATFPGVQMKFALQKLLTKVADAAKGYKPVPVPSEPEHNEAVADSTPLKQEWVWTQVGEFLREGDVVITETGTSAFGINQTHFPNNTYGISQVLWGSIGFTTGATLGAAFAAEEIDPKKRVILFIGDGSLQLTVQEISTMIRWGLKPYLFVLNNDGYTIERLIHGETAQYNCIQNWQHLELLPTFGAKDYEAVRVSTTGEWNKLTTDEKFQDNTRIRLIEVMLPTMDAPSNLVKQAQLTAATNAKN |
| Structure Information |
| PDB ID | 2VJY |
| Quaternary structure | |
| SCOP | DHS-like NAD/FAD-binding domain, Thiamin diphosphate-binding fold (THDP-binding) |
| CATH | 3.40.50.970, 3.40.50.1220, |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-5, 353, 555-563 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | pyruvate decarboxylase, 2-oxo acid -> an aldehyde + CO2 |
| References for function | Bianchi M.M., Tizzani L., Destruelle M., Frontall L., Wesolowski-Louvel M. The 'petite-negative' yeast Kluyveromyces lactis has a single gene expressing pyruvate decarboxylase activity. Mol. Microbiol. 19:27-36(1996). PMID: 8821934. |
| E.C. number | 4.1.1.1 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | transcriptional regulator but might not bind DNA directly (possibly by sequestering Rag3 in the cytoplasm), inhibits transcription from PDC1 and PDC5 promoters |
| References for function | 24763423, 10219994 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | transcriptional regulation does not require catalytic activity shown by studies with mutant protein |