| General Information |
| MoonProt ID | 383 |
| First appeared in release | 4.0 |
| Name(s) | NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial |
| UniProt ID | A0A5N4BYD0 |
| GO terms | GO:0008137 NADH dehydrogenase (ubiquinone) activity, GO:0010181 FMN binding, GO:0046872 metal ion binding, GO:0051287 NAD binding, GO:0051536 iron-sulfur cluster binding, GO:0051539 4 iron, 4 sulfur cluster binding, GO:0006120 mitochondrial electron transport, NADH to ubiquinone, GO:0042775 mitochondrial ATP synthesis coupled electron transport, GO:1902600 proton transmembrane transport, GO:0005743 mitochondrial inner membrane, GO:0045271 respiratory chain complex I |
| Organisms for which functions have been demonstrated | Camelus dromedarius (dromedary) Arabian camel |
| Sequence length | 464.0 |
| FASTA sequence | >tr|A0A5N4BYD0|A0A5N4BYD0_CAMDR NADH dehydrogenase [ubiquinone] flavoprotein 1, mitochondrial OS=Camelus dromedarius OX=9838 GN=Cadr_000030393 PE=3 SV=1 MLAARRLLGGSLPARVSVRFSGDTTAPKKTSFGSLKDEDRIFTNLYGRHDWRLKGAQSRG DWYKTKEILLKGPDWILGEVKTSGLRGRGGAGFPTGLKWSFMNKPSDGRPKYLVVNADEG EPGTCKDREIIRHDPHKLVEGCLVGGRAMGARAAYIYIRGEFYNEASNLQVAIREAYEAG LIGKNACGSGYDFDVFVVRGAGAYICGEETALIESIEGKQGKPRLKPPFPADVGVFGCPT TVANVETVAVSPTICRRGGAWFASFGRERNSGTKLFNISGHVNHPCTVEEEMSVPLKELI EKHAGGVTGGWDNLLAVIPGGSSTPLIPKSVCETVLMDFDALVQAQTGLGTAAVIVMDRS TDIVKAIARLIEFYKHESCGQCTPCREGVDWMNKVMARFVRGDARPAEIDSLWEISKQIE GHTICALGDGAAWPVQGLIRHFRPELEERMQRFAQQHQARQAAS |
| Structure Information |
| PDB ID | NA |
| Quaternary structure | Core component of respiratory chain |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | no entries found |
| Predicted Disorder Regions | N-terminus AA 1-6, 113-116, 127, 128, 450-464 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enzyme, NADPH:quinone oxidoreductase |
| References for function | Garland D, Rao PV, Del Corso A, Mura U, Zigler JS Jr. zeta-Crystallin is a major protein in the lens of Camelus dromedarius. Arch Biochem Biophys. 1991 Feb 15;285(1):134-6. doi: 10.1016/0003-9861(91)90339-k. PMID: 1990971. Duhaiman AS, Rabbani N, AlJafari AA, Alhomida AS. Purification and characterization of zeta-crystallin from the camel lens. Biochem Biophys Res Commun. 1995 Oct 13;215(2):632-40. doi: 10.1006/bbrc.1995.2511. PMID: 7488002. |
| E.C. number | EC:7.1.1.2 |
| Location of functional site(s) | |
| Cellular location of function | cytosol |
| Comments | |
| Function 2 |
| Function description | zeta-crystallin |
| References for function | Garland D, Rao PV, Del Corso A, Mura U, Zigler JS Jr. zeta-Crystallin is a major protein in the lens of Camelus dromedarius. Arch Biochem Biophys. 1991 Feb 15;285(1):134-6. doi: 10.1016/0003-9861(91)90339-k. PMID: 1990971. Duhaiman AS, Rabbani N, AlJafari AA, Alhomida AS. Purification and characterization of zeta-crystallin from the camel lens. Biochem Biophys Res Commun. 1995 Oct 13;215(2):632-40. doi: 10.1006/bbrc.1995.2511. PMID: 7488002. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | lens of eye |
| Comments | |