| General Information |
| MoonProt ID | 383 |
| First appeared in release | 2.0 |
| Name(s) | pyruvate kinase isozyme type M2, PKM2, M2-PK, PKM, Cytosolic thyroid hormone-binding protein, CTHBP, Opa-interacting protein 3, OIP-3, Pyruvate kinase 2/3, Pyruvate kinase muscle isozymem Thyroid hormone-binding protein 1, THBP1, Tumor M2-PK, p58, Gene: PKM |
| UniProt ID | P14618 (KPYM_HUMAN) |
| GO terms | GO:0006096 glycolytic process
GO:0008152 metabolic process
GO:0012501 programmed cell death
GO:0016310 phosphorylation
GO:0061621 canonical glycolysis
GO:0098609 cell-cell adhesion
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004743 pyruvate kinase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0016740 transferase activity
GO:0023026 MHC class II protein complex binding
GO:0030955 potassium ion binding
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
GO:0098641 cadherin binding involved in cell-cell adhesion
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0005913 cell-cell adherens junction
GO:0005929 cilium
GO:0031012 extracellular matrix
GO:0031982 vesicle
GO:0043209 myelin sheath
GO:0070062 extracellular exosome
GO:1903561 extracellular vesicle |
| Organisms for which functions have been demonstrated | Homo sapiens (human, a mammal) |
| Sequence length | 531 amino acids |
| FASTA sequence | >sp|P14618|KPYM_HUMAN Pyruvate kinase PKM OS=Homo sapiens GN=PKM PE=1 SV=4
MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP |
| Structure Information |
| PDB ID | 3GQY, 3SRD, 3U2Z, 4JPG, 4QGC, 4QG8, 4RPP, 3G2G, 4QG9, 1ZJH, 4FXF, 4B2D, 4WJ8, 4QG6, 3BJT, 1T5A, 4G1N, 3BJF, 4YJ5 |
| Quaternary structure | |
| SCOP | NA |
| CATH | 3.40.1380.20, 3.20.20.60, 2.40.33.10 |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-14, 399-406 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | pyruvate kinase, enzyme, glycolysis, ATP + pyruvate <=> ADP + phosphoenolpyruvate |
| References for function | |
| E.C. number | 2.7.1.40 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | regulates transcription, binds to Oct-4 protein |
| References for function | 18191611 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | nucleus |
| Comments | |