| General Information |
| MoonProt ID | 385 |
| First appeared in release | 2.0 |
| Name(s) | Leucyl aminopeptidase
Gene: pepA |
| UniProt ID | Q4A9M4 |
| GO terms | GO:0006508 proteolysis
GO:0019538 protein metabolic process
GO:0004177 aminopeptidase activity
GO:0008233 peptidase activity
GO:0008235 metalloexopeptidase activity
GO:0016787 hydrolase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0005622 intracellular
GO:0005737 cytoplasm |
| Organisms for which functions have been demonstrated | Mycoplasma hyopneumoniae |
| Sequence length | 459 amino acids |
| FASTA sequence | >tr|Q4A9M4|Q4A9M4_MYCHJ Leucyl aminopeptidase OS=Mycoplasma hyopneumoniae (strain J / ATCC 25934 / NCTC 10110) GN=pepA PE=4 SV=2
MKNFSEIFIKYSNKFESNRITIEPAYSDSQIPMLIKEDLAITEYLGQKKAYINLGSRSKELTPNRFRKIAAKLGHYPRDMQINFDKFPNSFLRYLIEVIAFQRSDIFSLRADYAKNRAKNRDILVVSSYLDELKPIIDKYQIINNSVNYARYYQNMPPNMASSEFLASEIQKKMNLNPKLTVKVLGENEVRKLGMNLLLAVNRGSTYDAKLVVISYEGLPGSQYKTAFIGKGITFDSGGYNIKTGMYMNDMKIDMSGAIICAAAIDALSQFNPLANVVAVLPLTDNRLNGDANTPDAVWRSMNGKTVEINNTDAEGRLILADAITYAIRQEKASEIISIATLTGAIRIALGETFTGAFANEEKIWKNFNEASKEAGELIWRMPLHQDFAQNIRDSKVADLKNTDFSGKAGSSSAAMFLAEFVEDKPFIHLDIAATAFVKNTPTGVMVRSLVEYILAKQN |
| Structure Information |
| PDB ID | |
| Quaternary structure | |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-9, 110-117, 457-459 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | leucine aminopeptidase (LAP) |
| References for function | 25589579 |
| E.C. number | EC:3.4.11.1 |
| Location of functional site(s) | |
| Cellular location of function | Cell surface of Mycoplasma hyopneumoniae (pg 4) |
| Comments | |
| Function 2 |
| Function description | binds to heparin |
| References for function | Jarocki VM, Santos J, Tacchi JL, Raymond BB, Deutscher AT, Jenkins C, Padula MP, Djordjevic SP. MHJ_0461 is a multifunctional leucine aminopeptidase on the surface of Mycoplasma hyopneumoniae. Open Biol. 2015 Jan;5(1):140175. doi: 10.1098/rsob.140175. PMID: 25589579. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | Cell surface of Mycoplasma hyopneumoniae |
| Comments | |