| General Information |
| MoonProt ID | 388 |
| First appeared in release | 2.0 |
| Name(s) | RPT5B, 26S protease regulatory subunit 6A homolog B, 26S proteasome AAA-ATPase subunit RPT5b, Proteasome 26S subunit 6A homolog B, Regulatory particle triple-A ATPase subunit 5b, Tat-binding protein 1 homolog B, TBP-1 homolog B, Gene: RPT5B |
| UniProt ID | O04019 (PS6AB_ARATH) |
| GO terms | GO:0009553 embryo sac development
GO:0009555 pollen development
GO:0010255 glucose mediated signaling pathway
GO:0010498 proteasomal protein catabolic process
GO:0030163 protein catabolic process
GO:0030433 ER-associated ubiquitin-dependent protein catabolic process
GO:0045899 positive regulation of RNA polymerase II transcriptional preinitiation complex assembly
GO:1901800 positive regulation of proteasomal protein catabolic process
GO:0000166 nucleotide binding
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0017025 TBP-class protein binding
GO:0036402 proteasome-activating ATPase activity
GO:0000502 proteasome complex
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005886 plasma membrane
GO:0008540 proteasome regulatory particle, base subcomplex
GO:0016020 membrane
GO:0031595 nuclear proteasome complex
GO:0031597 cytosolic proteasome complex |
| Organisms for which functions have been demonstrated | Arabidopsis thaliana (Mouse-ear cress, a plant) |
| Sequence length | 423 amino acids |
| FASTA sequence | >sp|O04019|PS6AB_ARATH 26S protease regulatory subunit 6A homolog B OS=Arabidopsis thaliana GN=RPT5B PE=1 SV=3
MATAMAEDTSFEGDQLASMTTDDIGRASRLLANEIRILKEESQRTNLDLESVKEKIKENQEKIKLNKQLPYLVGNIVEILEMSPEDDAEEDGANIDLDSQRKGKCVVLKTSTRQTIFLPVVGLVDPDTLKPGDLVGVNKDSYLILDTLPSEYDSRVKAMEVDEKPTEDYNDIGGLEKQIQELVEAIVLPMTHKEQFEKLGIRPPKGVLLYGPPGTGKTLMARACAAQTNATFLKLAGPQLVQMFIGDGAKLVRDAFLLAKEKSPCIIFIDEIDAIGTKRFDSEVSGDREVQRTMLELLNQLDGFSSDDRIKVIAATNRADILDPALMRSGRLDRKIEFPHPTEEARGRILQIHSRKMNVNADVNFEELARSTDDFNGAQLKAVCVEAGMLALRRDATEVNHEDFNEGIIQVQAKKKASLNYYA |
| Structure Information |
| PDB ID | |
| Quaternary structure | |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | Predicted disorder at N terminus (aa 1-11), middle region (aa 13-15, 89-94, 157-161, 168-172, 336, 348), and C terminus (aa 419-423) |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | part of the regulatory ATPase complex of the 26S proteasome, confers substrate specificity and need for ATP to the proteaseome |
| References for function | |
| E.C. number | N/A |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | binds to hexokinase 1 and VHA B1 to modulate transcription of specific target genes |
| References for function | 17081979 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | nucleus |
| Comments | |