General Information |
MoonProt ID | 392 |
First appeared in release | 2.0 |
Name(s) | threonyl aminoacyl-tRNA synthetase, TARS, Threonine-tRNA ligase, cytoplasmic, Gene:TARS |
UniProt ID | A8KC60 (A8KC60_DANRE) |
GO terms | GO:0001944 vasculature development
GO:0006418 tRNA aminoacylation for protein translation
GO:0006435 threonyl-tRNA aminoacylation
GO:0043039 tRNA aminoacylation
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004829 threonine-tRNA ligase activity
GO:0005524 ATP binding
GO:0016876 ligase activity, forming aminoacyl-tRNA and related compounds
GO:0005737 cytoplasm |
Organisms for which functions have been demonstrated | Danio rerio (Zebrafish) (Brachydanio rerio) |
Sequence length | 718 amino acids |
FASTA sequence | >tr|A8KC60|A8KC60_DANRE Zgc:92586 protein OS=Danio rerio GN=tars PE=2 SV=1
MADESVTDQLKELKMEEKKNTKDGGKKKNKNAAGDSGGKTELSPPPQYIDERLSIYNKLKEEHDALLAEKAAKESKPIKITLPDGKVVDGESWKTTPYQVACGISQGLADNTVISKVNNGVWDLDRPLEEDCSLVFLKFDDEEAQAVYWHSSAHIMGEAMERVYGGCLCYGPPIENGFYYDMYLDNEGVSSNDFPCLENLCKKIIKEKQPFERLEVKKETLLEMFKYNKFKCRILNEKVTTPTTTVYRCGPLIDLCRGPHVRHTGKIKAMKIHKNSSTYWEGKADMESLQRIYGISFPDPKMLKEWEKFQEEAKNRDHRKLGREQDLFFFHDLSPGSCFFLPKGAYIYNTLIEFIRSEYRKRGFQEVVTPNIYNSKLWQTSGHWQHYSENMFSFEVEKEIFALKPMNCPGHCLMFDHRPRSWRELPLRLADFGVLHRNELSGALTGLTRVRRFQQDDAHIFCSMDQIESEIKGCLDFLRTVYDVFGFTFKLNLSTRPEKFLGEPEVWDQAEKQLENSLNDFGEKWVLNPGDGAFYGPKIDIQIKDAIGRYHQCATIQLDFQLPIRFNLTFVSHDGDDKKRPVIIHRAILGSVERMIAILTENYGGKWPLWLSPRQVMVVPIGPTCDEYAQRVQKEFHKVGLMTDVDLDPGCTLNKKIRNAQLAQYNFILVVGEKEKSSDTVNVRTRDNKVHGERSLTDCMERLKQLKASRTRNAEEEF |
Structure Information |
PDB ID | |
Quaternary structure | |
SCOP | |
CATH | |
TM Helix Prediction | no TM helices |
DisProt Annotation | Not in DisProt |
Predicted Disorder Regions | 1-41, 69-72, 690-692, 708-718 |
Connections to Disease |
OMIM ID | |
Function 1 |
Function description | threonyl aminoacyl-tRNA synthetase, attaches threonine to tRNA, early step in protein synthesis, ATP + L-threonine + tRNA(Thr) -> AMP + diphosphate + L-threonyl-tRNA(Thr) |
References for function | |
E.C. number | 6.1.1.3 |
Location of functional site(s) | |
Cellular location of function | cytoplasm |
Comments | |
Function 2 |
Function description | promotes vascular development, demostrated this is separate from role in protein synthesis |
References for function | 26271225 |
E.C. number | |
Location of functional site(s) | |
Cellular location of function | extracellular |
Comments | secreted from endothelial cells in response to TNF-? and VEGF, association between TARS expression and advancing stage of ovarian cancer, mutation that prevents synthetase activity is still active in promoting vascular development, single amino acid substitutions in TARS can block the anti-angiogenic effects of BC194, indicating that TARS is the specific target of BC194 |