| General Information |
| MoonProt ID | 396 |
| First appeared in release | 2.0 |
| Name(s) | VHA-B1, V-type proton ATPase subunit B1, Gene: VHA-B1 |
| UniProt ID | P11574 (VATB1_ARATH) |
| GO terms | GO:0006810 transport
GO:0006811 ion transport
GO:0010255 glucose mediated signaling pathway
GO:0015991 ATP hydrolysis coupled proton transport
GO:0015992 proton transport
GO:0030835 negative regulation of actin filament depolymerization
GO:0046034 ATP metabolic process
GO:0046686 response to cadmium ion
GO:0051017 actin filament bundle assembly
GO:0051693 actin filament capping
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
GO:0051015 actin filament binding
GO:0005773 vacuole
GO:0005774 vacuolar membrane
GO:0005794 Golgi apparatus
GO:0005886 plasma membrane
GO:0009506 plasmodesma
GO:0009507 chloroplast
GO:0016020 membrane
GO:0033180 proton-transporting V-type ATPase, V1 domain
GO:0005829 cytosol |
| Organisms for which functions have been demonstrated | Arabidopsis thaliana (Mouse-ear cress, a plant) |
| Sequence length | 486 amino acids |
| FASTA sequence | >sp|P11574|VATB1_ARATH V-type proton ATPase subunit B1 OS=Arabidopsis thaliana GN=VHA-B1 PE=2 SV=2
MGTNDLDIEEGTLEIGMEYRTVSGVAGPLVILDKVKGPKYQEIVNIRLGDGSTRRGQVLEVDGEKAVVQVFEGTSGIDNKFTTVQFTGEVLKTPVSLDMLGRIFNGSGKPIDNGPPILPEAYLDISGSSINPSERTYPEEMIQTGISTIDVMNSIARGQKIPLFSAAGLPHNEIAAQICRQAGLVKRLEKTVDLLEDHGEDNFAIVFAAMGVNMETAQFFKRDFEENGSMERVTLFLNLANDPTIERIITPRIALTTAEYLAYECGKHVLVILTDMSSYADALREVSAAREEVPGRRGYPGYMYTDLATIYERAGRIEGRKGSITQIPILTMPNDDITHPTPDLTGYITEGQIYIDRQLHNRQIYPPINVLPSLSRLMKSAIGEGMTRKDHSDVSNQLYANYAIGKDVQAMKAVVGEEALSSEDLLYLEFLDKFERKFVMQGAYDTRNIFQSLDLAWTLLRIFPRELLHRIPAKTLDQFYSRDSTS |
| Structure Information |
| PDB ID | |
| Quaternary structure | |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | 1-13, 191-195, 382-386, 481-486 |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | subunit of the peripheral V1 complex of vacuolar ATPase. V-ATPase functions in acidifying several intracellular compartments in eukaryotic cells |
| References for function | |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | membrane |
| Comments | |
| Function 2 |
| Function description | binds to hexokinase 1 and the 19S regulatory particle of proteasome subunit (RPT5B) to modulate transcription of specific target genes |
| References for function | 17081979 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | nucleus |
| Comments | |