| General Information |
| MoonProt ID | 398 |
| First appeared in release | 2.0 |
| Name(s) | VPS25, Vacuolar protein-sorting-associated protein 25, ESCRT-II complex subunit VPS25, Vacuolar protein sorting 25 Gene: Vps25 |
| UniProt ID | Q7JXV9 (VPS25_DROME) |
| GO terms | GO:0006810 transport
GO:0007293 germarium-derived egg chamber formation
GO:0008105 asymmetric protein localization
GO:0008283 cell proliferation
GO:0008593 regulation of Notch signaling pathway
GO:0010669 epithelial structure maintenance
GO:0010669 epithelial structure maintenance
GO:0015031 protein transport
GO:0016197 endosomal transport
GO:0019233 sensory perception of pain
GO:0030154 cell differentiation
GO:0030713 ovarian follicle cell stalk formation
GO:0032509 endosome transport via multivesicular body sorting pathway
GO:0042059 negative regulation of epidermal growth factor receptor signaling pathway
GO:0042981 regulation of apoptotic process
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0045199 maintenance of epithelial cell apical/basal polarity
GO:0045450 bicoid mRNA localization
GO:0048803 imaginal disc-derived male genitalia morphogenesis
GO:0050680 negative regulation of epithelial cell proliferation
GO:0060429 epithelium development
GO:0070086 ubiquitin-dependent endocytosis
GO:0097352 autophagosome maturation
GO:0005198 structural molecule activity
GO:0042803 protein homodimerization activity
GO:0000814 ESCRT II complex
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0010008 endosome membrane
GO:0016020 membrane |
| Organisms for which functions have been demonstrated | Drosophila melanogaster (fruit fly, an insect) |
| Sequence length | 174 amino acids |
| FASTA sequence | >sp|Q7JXV9|VPS25_DROME Vacuolar protein-sorting-associated protein 25 OS=Drosophila melanogaster GN=Vps25 PE=1 SV=1
MAEFQWPWEYTFPPFFTLQPHEETRQQQLKVWTDLFLKYLRHTNRFTLSIGDQNSPLFHNEALKRRLSPELVLAILGELERSGHANPLDKRRQEWQVYWFTLEEYGNMVYDWVQETGQTNTICTLYEIASGENTSHLDFYGVDEAVLLSALRLLEEKGRCELIEMDGSHGVKFF |
| Structure Information |
| PDB ID | none, but structures of homologues are available |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | Use FASTA sequence on the MFDp2 webserver.
moonID_398_uniID_Q7JXV9 is 174 residues long, with 0 residues (0.00%) predicted as disordered.The protein has 0 short (< 30 residues) disorder segments and 0 long (>= 30 residues) disorder segments. |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | component of ESCRT-II (endosomal sorting complex required for transport), functions in exosomal sorting pathway that sorts ubiquitinated endosomal proteins into internal vesicles |
| References for function | |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | |
| Function 2 |
| Function description | bind bicoid mRNA to cause localization to anterior of egg |
| References for function | Irion U, St Johnston D. (2007) bicoid RNA localization requires specific binding of an endosomal sorting complex. Nature 445, 554–558. PMID: 17268469. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | egg |
| Comments | |