Protein Information

General Information
MoonProt ID399
First appeared in release2.0
Name(s)VPS36, Vacuolar protein-sorting-associated protein 36, ESCRT-II complex subunit VPS36 Gene: Vps36
UniProt IDQ9VU87 (VPS36_DROME)
GO termsGO:0006810 transport GO:0007224 smoothened signaling pathway GO:0008105 asymmetric protein localization GO:0008283 cell proliferation GO:0008593 regulation of Notch signaling pathway GO:0015031 protein transport GO:0019233 sensory perception of pain GO:0042981 regulation of apoptotic process GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway GO:0045450 bicoid mRNA localization GO:0051028 mRNA transport GO:0003723 RNA binding GO:0003730 mRNA 3'-UTR binding GO:0032266 phosphatidylinositol-3-phosphate binding GO:0043130 ubiquitin binding GO:0000814 ESCRT II complex GO:0005737 cytoplasm GO:0005768 endosome GO:0031902 late endosome membrane
Organisms for which functions have been demonstratedDrosophila melanogaster
Sequence length399 amino acids
FASTA sequence>sp|Q9VU87|VPS36_DROME Vacuolar protein-sorting-associated protein 36 OS=Drosophila melanogaster GN=Vps36 PE=2 SV=2 MNRFAYVEARLSPNESFVSRDNRVKIYDGDQKTDFEDGEVVLTTHRLFWGRPGEIARAAVTLCLPLSYVISVSEETTASNFFGRKTRIIMHLHPPTSDKGPGPLDTSRATHIKLSGKNGLSVEFHSALRETLNARVWEILLTSEIIINGVASSPTLEPANDRLARIQKRTGIGGIERHLEAKAKATDENIALAFQDLSVLMAMAKDMVGVSKTISSKIRKQKGEISDDETVRFKSYLMSLGIDDPVTRDNFTSNSAYFSSLARQICEMLLDPIEEQGGMMSLADVYCRVNRARGLELLSPEDLLHACEQLSGPIRLRSFPSGARVLQLESHDDALIAVDTLEKVEAAESLAVEELAKQLGISLLLAKERLLVAERLGKVCRDESVEGLRFYPNLLLGRD
Structure Information
PDB IDnone, but structures of human homologue available
Quaternary structure
Function 1
Function descriptioncomponent of ESCRT-II (endosomal sorting complex required for transport), functions in exosomal sorting pathway that sorts ubiquitinated endosomal proteins into internal vesicles
References for function
E.C. number
Location of functional site(s)
Cellular location of function
Comments
Function 2
Function descriptionbind bicoid mRNA to cause localization to anterior of egg, binding directly and specifically to stem-loop V of the bicoid 39 UTR
References for function17268469
E.C. number
Location of functional site(s)
Cellular location of functionegg
Comments