| General Information |
| MoonProt ID | 399 |
| First appeared in release | 2.0 |
| Name(s) | VPS36, Vacuolar protein-sorting-associated protein 36, ESCRT-II complex subunit VPS36 Gene: Vps36 |
| UniProt ID | Q9VU87 (VPS36_DROME) |
| GO terms | GO:0006810 transport
GO:0007224 smoothened signaling pathway
GO:0008105 asymmetric protein localization
GO:0008283 cell proliferation
GO:0008593 regulation of Notch signaling pathway
GO:0015031 protein transport
GO:0019233 sensory perception of pain
GO:0042981 regulation of apoptotic process
GO:0043162 ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0043328 protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
GO:0045450 bicoid mRNA localization
GO:0051028 mRNA transport
GO:0003723 RNA binding
GO:0003730 mRNA 3'-UTR binding
GO:0032266 phosphatidylinositol-3-phosphate binding
GO:0043130 ubiquitin binding
GO:0000814 ESCRT II complex
GO:0005737 cytoplasm
GO:0005768 endosome
GO:0031902 late endosome membrane |
| Organisms for which functions have been demonstrated | Drosophila melanogaster (fruit fly, an insect) |
| Sequence length | 399 amino acids |
| FASTA sequence | >sp|Q9VU87|VPS36_DROME Vacuolar protein-sorting-associated protein 36 OS=Drosophila melanogaster GN=Vps36 PE=2 SV=2
MNRFAYVEARLSPNESFVSRDNRVKIYDGDQKTDFEDGEVVLTTHRLFWGRPGEIARAAVTLCLPLSYVISVSEETTASNFFGRKTRIIMHLHPPTSDKGPGPLDTSRATHIKLSGKNGLSVEFHSALRETLNARVWEILLTSEIIINGVASSPTLEPANDRLARIQKRTGIGGIERHLEAKAKATDENIALAFQDLSVLMAMAKDMVGVSKTISSKIRKQKGEISDDETVRFKSYLMSLGIDDPVTRDNFTSNSAYFSSLARQICEMLLDPIEEQGGMMSLADVYCRVNRARGLELLSPEDLLHACEQLSGPIRLRSFPSGARVLQLESHDDALIAVDTLEKVEAAESLAVEELAKQLGISLLLAKERLLVAERLGKVCRDESVEGLRFYPNLLLGRD |
| Structure Information |
| PDB ID | none, but structures of human homologue available |
| Quaternary structure | |
| SCOP | NA |
| CATH | NA |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | Not in DisProt |
| Predicted Disorder Regions | Use FASTA sequence on the MFDp2 webserver.
moonID_399_uniID_Q9VU87 is 399 residues long, with 64 residues (16.04%) predicted as disordered.The protein has 2 short (< 30 residues) disorder segments and 1 long (>= 30 residues) disorder segment.
Segment 1 - Long (>= 30 residues) disordered segment Segment is located between positions 79 and 109 in the sequence. The segment is 31 residues long (7.77 % of the total sequence length).
Segment 2 - Short (< 30 residues) disordered segment Segment is located between positions 145 and 168 in the sequence. The segment is 24 residues long (6.02 % of the total sequence length).
Segment 3 - Short (< 30 residues) disordered segment Segment is located between positions 220 and 228 in the sequence. The segment is 9 residues long (2.26 % of the total sequence length). |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | component of ESCRT-II (endosomal sorting complex required for transport), functions in exosomal sorting pathway that sorts ubiquitinated endosomal proteins into internal vesicles |
| References for function | |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | |
| Comments | OMIM number 103850 Glycogen storage disease XII |
| Function 2 |
| Function description | bind bicoid mRNA to cause localization to anterior of egg, binding
directly and specifically to stem-loop V of the bicoid 39 UTR |
| References for function | 17268469 |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | egg |
| Comments | |