| General Information |
| MoonProt ID | 40 |
| First appeared in release | 4.0 |
| Name(s) | phosphomannomutase 1 |
| UniProt ID | Q82971 |
| GO terms | "GO:0005198 structural molecule activity ; GO:0019028 viral capsid ; GO:0042025 host cell nucleus ; GO:0044423 virion component" |
| Organisms for which functions have been demonstrated | Homo Sapiens. Human herpesvirus 8 (HHV-8) (Kaposi's sarcoma-associated herpesvirus) |
| Sequence length | 262.0 |
| FASTA sequence | >sp|Q92871|PMM1_HUMAN Phosphomannomutase 1 OS=Homo sapiens OX=9606 GN=PMM1 PE=1 SV=2 MAVTAQAARRKERVLCLFDVDGTLTPARQKIDPEVAAFLQKLRSRVQIGVVGGSDYCKIA EQLGDGDEVIEKFDYVFAENGTVQYKHGRLLSKQTIQNHLGEELLQDLINFCLSYMALLR LPKKRGTFIEFRNGMLNISPIGRSCTLEERIEFSELDKKEKIREKFVEALKTEFAGKGLR FSRGGMISFDVFPEGWDKRYCLDSLDQDSFDTIHFFGNETSPGGNDFEIFADPRTVGHSV VSPQDTVQRCREIFFPETAHEA |
| Structure Information |
| PDB ID | 2FUC, 2FUE, 6CFR, 6CFS, 6CFT, 6CFU, 6CFV |
| Quaternary structure | NA |
| SCOP | |
| CATH | |
| TM Helix Prediction | no TM helices |
| DisProt Annotation | |
| Predicted Disorder Regions | Predicted disorder at N terminus (aa 1-3), and C terminus (aa 61-64) |
| Connections to Disease |
| OMIM ID | |
| Function 1 |
| Function description | enzyme, catalyzes the interconversion of hexose 6-phosphates and hexose 1-phosphates |
| References for function | Ji T, Zhang C, Zheng L, Dunaway-Mariano D, Allen KN. Structural Basis of the Molecular Switch between Phosphatase and Mutase Functions of Human Phosphomannomutase 1 under Ischemic Conditions. Biochemistry. 2018 Jun 26;57(25):3480-3492. doi: 10.1021/acs.biochem.8b00223. Epub 2018 May 11. PMID: 29695157; PMCID: PMC10251306. |
| E.C. number | 5.4.2.8 |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |
| Function 2 |
| Function description | enzyme, phosphohydrolase, converts glucose 1,6-bisphosphate to glucose 6-phosphate |
| References for function | Ji T, Zhang C, Zheng L, Dunaway-Mariano D, Allen KN. Structural Basis of the Molecular Switch between Phosphatase and Mutase Functions of Human Phosphomannomutase 1 under Ischemic Conditions. Biochemistry. 2018 Jun 26;57(25):3480-3492. doi: 10.1021/acs.biochem.8b00223. Epub 2018 May 11. PMID: 29695157; PMCID: PMC10251306. |
| E.C. number | |
| Location of functional site(s) | |
| Cellular location of function | cytoplasm |
| Comments | |